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Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival
dc.creator | Šuvakov, Sonja | |
dc.creator | Jerotić, D | |
dc.creator | Damjanović, Tatjana | |
dc.creator | Milić, N | |
dc.creator | Pekmezović, T | |
dc.creator | Đukić, Tatjana | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Savić-Radojević, Ana | |
dc.creator | Pljesa-Ercegovac, Marija | |
dc.creator | Matić, Marija | |
dc.creator | McClements, L | |
dc.creator | Dimković, Nada | |
dc.creator | Garović, V.D | |
dc.creator | Albright, R.C | |
dc.creator | Simić, Tatjana | |
dc.date.accessioned | 2019-09-02T12:09:19Z | |
dc.date.available | 2019-09-02T12:09:19Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0250-8095 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3277 | |
dc.description.abstract | Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p lt 0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups. | en |
dc.publisher | S. Karger AG | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175052/RS// | |
dc.rights | restrictedAccess | |
dc.source | American Journal of Nephrology | |
dc.subject | Endothelial dysfunction | en |
dc.subject | Gene polymorphism | en |
dc.subject | Haemodialysis | en |
dc.subject | Oxidative stress | en |
dc.subject | Survival analysis | en |
dc.title | Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aлбригхт, Р.Ц; Шуваков, Соња; Димковић, Нада; Матић, Марија; Пљеса-Ерцеговац, Марија; Савић-Радојевић, Aна; Симић, Татјана; Ђукић, Татјана; Јеротић, Д; Дамјановић, Татјана; Милић, Н; МцЦлементс, Л; Јелић-Ивановић, Зорана; Гаровић, В.Д; Пекмезовић, Т; | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000480262300004 | |
dc.identifier.doi | 10.1159/000501300 | |
dc.identifier.scopus | 2-s2.0-85068526930 | |
dc.type.version | publishedVersion |