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dc.creatorObradović, Darija
dc.creatorStavrianidi, A.N
dc.creatorUstinovich, K.B
dc.creatorParenago, O.O
dc.creatorShpigun, O.A
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T12:09:28Z
dc.date.available2019-09-02T12:09:28Z
dc.date.issued2019
dc.identifier.issn0021-9673
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3282
dc.description.abstractThis work presents an investigation of retention characteristics of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction liquid chromatography (NA-HILIC) and supercritical fluid chromatography (SFC). The separation has been carried out by using methanol as a mobile phase modifier with addition of two types of additives (NH 4 HCOO; NH 4 HCOO/HCOOH) and two different stationary phases (diol; mixed-mode diol). The selectivity characteristics were observed based on S-factors, logk-logk plots and radar plots. NA-HILIC vs. SFC retention of tested compounds was also described by considering the molecular properties of the analytes within the LSER analysis. The differences between SFC vs. NA-HILIC retention of imidazoline and serotonin receptor ligands grow with the acid addition to a mobile phase, noticeably on mixed-mode diol stationary phase (S ≥ 87). In addition, the good selectivity performances of the certain NA-HILIC and SFC conditions were confirmed by good separation of structurally related compounds (α ≥ 2). The molecular basis of NA-HILIC and SFC retention were explained by using Abraham's equation. The dominant analyte descriptors influencing retention were hydrogen bonding and dipolar interactions. The current study will present the theory, and discuss the applicability within the SFC vs. NA-HILIC regimes. In this way, it was provided the placing of two relatively new methods (SFC, NA-HILIC) in the map of modern analytical chromatography in terms of the pharmaceutical analysis.en
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Chromatography A
dc.subjectLinear solvation energy relationshipen
dc.subjectNon-aqueous hydrophilic interaction liquid chromatographyen
dc.subjectRetention mechanismen
dc.subjectSelectivityen
dc.subjectSupercritical fluid chromatographyen
dc.titleThe comparison of retention behaviour of imidazoline and serotonin receptor ligands in non-aqueous hydrophilic interaction chromatography and supercritical fluid chromatographyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAгбаба, Даница; Ставрианиди, A.Н; Схпигун, О.A; Паренаго, О.О; Устиновицх, К.Б; Обрадовић, Дарија;
dc.citation.rankM21
dc.identifier.wos000484871200038
dc.identifier.doi10.1016/j.chroma.2019.04.054
dc.identifier.scopus2-s2.0-85065033746
dc.type.versionpublishedVersion


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Приказ основних података о документу