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dc.creatorBecarević, Mirjana
dc.creatorNikolić, B.S
dc.creatorIgnjatović, Svetlana
dc.date.accessioned2019-09-02T12:09:35Z
dc.date.available2019-09-02T12:09:35Z
dc.date.issued2019
dc.identifier.issn0172-8172
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3287
dc.description.abstractThe antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of the IgG and/or IgM isotypes of the antiphospholipid antibodies, thrombosis and/or recurrent pregnancy losses. Various markers of inflammation are associated with clinical and/or laboratory features of APS. Adiponectin (Ad) is a member of the adipocytokines that exert its roles by binding to its receptors (AdR). Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists induced Ad production. The aged Pparg null-mice represented the first animal model that spontaneously develops APS and this model emphasized the importance of PPAR-gamma signaling in the development of APS. Recombinant Ad (rAd) application was beneficial for the improvement of glucose, insulin and lipid levels in mice. Orally active AdR agonist exerted similar effects to Ad in mice. Due to the re-occurrence of thrombotic episodes in APS patients (despite life-long anticoagulation), administration of PPAR-gamma agonists, rAd, or AdR agonists should be further tested in experimental models of APS, which eventually, will provide more data for novel therapeutic strategies that will ameliorate clinical manifestations of the APS.en
dc.publisherSpringer Verlag
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceRheumatology International
dc.subjectAdiponectinen
dc.subjectAntiphospholipid antibodiesen
dc.subjectAntiphospholipid syndromeen
dc.subjectInflammationen
dc.subjectPPAR-gamma agonisten
dc.titleAdiponectin: a therapeutic target in the antiphospholipid syndrome?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБецаревић, Мирјана; Игњатовић, Светлана; Николић, Б.С;
dc.citation.rankM23
dc.identifier.wos000478892000004
dc.identifier.doi10.1007/s00296-019-04349-x
dc.identifier.scopus2-s2.0-85067645374
dc.identifier.rcubconv_4542
dc.type.versionpublishedVersion


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