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dc.creatorKlisić, Aleksandra
dc.creatorKavarić, Nebojša
dc.creatorNinić, Ana
dc.date.accessioned2019-09-02T12:09:39Z
dc.date.available2019-09-02T12:09:39Z
dc.date.issued2019
dc.identifier.issn1452-8258
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3288
dc.description.abstractAlanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the fatty liver disease. A total of 771 volunteers were enrolled. A fatty liver index (FLI) score ≥60 was used as proxy of NAFLD. The receiver operating characteristic curve analysis with the area under the curve (AUC) was used to determine the cut-off values of ALT and uric acid associated with FLI ≥60. ALT was independent predictor of FLI in both men and women, whereas serum uric acid was its independent predictor only in women. Lower cut-off levels of ALT are associated with the increased prevalence of NAFLD [i.e., ALT was 19 IU/L (AUC=0.746, sensitivity 63%, specificity 72%, P lt 0.001) in women and 22 IU/L (AUC=0.804, sensitivity 61%, specificity 95%, P lt 0.001) in men]. The cut-off value for uric acid was 274 μmol/L (AUC=0.821, sensitivity 68%, specificity 82%, P lt 0.001) in women. Lower cut-off levels of ALT in both genders, and serum uric acid in females, can be reliable predictors of the FLI.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectfatty liveren
dc.subjecthyperuricemiaen
dc.subjectinflammationen
dc.subjectobesityen
dc.subjecttransaminasesen
dc.titlePredictive values of serum uric acid and Alanine-aminotransferase for fatty liver index in Montenegrin populationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНинић, Aна; Клисић, Aлександра; Каварић, Небојша;
dc.citation.rankM23
dc.identifier.wos000478797600002
dc.identifier.doi10.2478/jomb-2019-0001
dc.identifier.scopus2-s2.0-85063750687
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1859/3286.pdf
dc.identifier.rcubconv_4541
dc.type.versionpublishedVersion


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