It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ionic strength μ = 0.55 M, is found to be 105.3. The molar absorptivity at 355 nm is 3.16 × 104 l mol-1 cm-1 at pH 6.3. Beer's law is obeyed up to 20 μmol l-1 obidoxime chloride concentration. The detection limit of the method is 0.36 μg ml-1. The relative standard deviation (n = 10) varies over the range 1.10-2.66%. The proposed method was found to be suitable for the accurate and sensitive analysis of obidoxime chloride in water and injection solutions.
TY - JOUR
AU - Karljiković-Rajić, Katarina
AU - Stanković, B
AU - Binenfeld, Z.J.
PY - 1987
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/33
AB - It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ionic strength μ = 0.55 M, is found to be 105.3. The molar absorptivity at 355 nm is 3.16 × 104 l mol-1 cm-1 at pH 6.3. Beer's law is obeyed up to 20 μmol l-1 obidoxime chloride concentration. The detection limit of the method is 0.36 μg ml-1. The relative standard deviation (n = 10) varies over the range 1.10-2.66%. The proposed method was found to be suitable for the accurate and sensitive analysis of obidoxime chloride in water and injection solutions.
T2 - Journal of Pharmaceutical and Biomedical Analysis
T1 - Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections
VL - 5
IS - 2
SP - 141
EP - 149
DO - 10.1016/0731-7085(87)80016-X
ER -
@article{
author = "Karljiković-Rajić, Katarina and Stanković, B and Binenfeld, Z.J.",
year = "1987",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/33",
abstract = "It has been established that obidoxime chloride reacts with palladium(II) chloride in the pH range 3.9-8.0 and forms a yellow water-soluble (1:1) complex with maximum absorbance at 355 nm. By applying the methods of Sommer, Nash and Job involving non-equimolar solutions the conditional stability constant of the complex, at the optimum pH of 6.3 and an ionic strength μ = 0.55 M, is found to be 105.3. The molar absorptivity at 355 nm is 3.16 × 104 l mol-1 cm-1 at pH 6.3. Beer's law is obeyed up to 20 μmol l-1 obidoxime chloride concentration. The detection limit of the method is 0.36 μg ml-1. The relative standard deviation (n = 10) varies over the range 1.10-2.66%. The proposed method was found to be suitable for the accurate and sensitive analysis of obidoxime chloride in water and injection solutions.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections",
volume = "5",
number = "2",
pages = "141-149",
doi = "10.1016/0731-7085(87)80016-X"
}
Karljiković-Rajić, K., Stanković, B.,& Binenfeld, Z.J. (1987). Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections.
Journal of Pharmaceutical and Biomedical Analysis, 5(2), 141-149.
https://doi.org/10.1016/0731-7085(87)80016-X
Karljiković-Rajić K, Stanković B, Binenfeld Z. Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections. Journal of Pharmaceutical and Biomedical Analysis. 1987;5(2):141-149
Karljiković-Rajić Katarina, Stanković B, Binenfeld Z.J., "Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections" Journal of Pharmaceutical and Biomedical Analysis, 5, no. 2 (1987):141-149,
https://doi.org/10.1016/0731-7085(87)80016-X .
