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dc.creatorSuryanegara, Jose
dc.creatorCassidy, Sophie
dc.creatorNinković, Vladan
dc.creatorPopović, Dejana
dc.creatorGrbović, Miljan
dc.creatorOkwose, Nduka
dc.creatorTrenell, Michael I.
dc.creatorMacGowan, Guy G.
dc.creatorJakovljević, Đorđe G.
dc.date.accessioned2019-09-02T12:10:03Z
dc.date.available2019-09-02T12:10:03Z
dc.date.issued2019
dc.identifier.issn0940-5429
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3303
dc.description.abstractAimThe present study assessed the effect of high intensity interval training on cardiac function during prolonged submaximal exercise in patients with type 2 diabetes.MethodsTwenty-six patients with type 2 diabetes were randomized to a 12 week of high intensity interval training (3 sessions/week) or standard care control group. All patients underwent prolonged (i.e. 60min) submaximal cardiopulmonary exercise testing (at 50% of previously assess maximal functional capacity) with non-invasive gas-exchange and haemodynamic measurements including cardiac output and stroke volume before and after the intervention.ResultsAt baseline (prior to intervention) there was no significant difference between the intervention and control group in peak exercise oxygen consumption (20.36.1 vs. 21.75.5ml/kg/min, p=0.21), and peak exercise heart rate (156.3 +/- 15.0 vs. 153.8 +/- 12.5 beats/min, p=0.28). During follow-up assessment both groups utilized similar amount of oxygen during prolonged submaximal exercise (15.0 +/- 2.4 vs. 15.2 +/- 2.2ml/min/kg, p=0.71). However, cardiac function i.e. cardiac output during submaximal exercise decreased significantly by 21% in exercise group (16.2 +/- 2.7-12.8 +/- 3.6L/min, p=0.03), but not in the control group (15.7 +/- 4.9-16.3 +/- 4.1L/min, p=0.12). Reduction in exercise cardiac output observed in the exercise group was due to a significant decrease in stroke volume by 13% (p=0.03) and heart rate by 9% (p=0.04).Conclusion Following high intensity interval training patients with type 2 diabetes demonstrate reduced cardiac output during prolonged submaximal cardiopulmonary exercise testing. Ability of patients to maintain prolonged increased metabolic demand but with reduced cardiac output suggests cardiac protective role of high intensity interval training in type 2 diabetes.Trial registration ISRCTN78698481. Registered 23 January 2013, retrospectively registered.en
dc.publisherSpringer-Verlag Italia Srl, Milan
dc.relationUK National Institute for Health Research Newcastle Biomedical Research Centre in Ageing and Long-Te
dc.rightsopenAccess
dc.sourceActa Diabetologica
dc.subjectCardiac functionen
dc.subjectType 2 diabetesen
dc.subjectHIITen
dc.subjectSubmaximal exerciseen
dc.titleHigh intensity interval training protects the heart during increased metabolic demand in patients with type 2 diabetes: a randomised controlled trialen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТренелл, Мицхаел И.; Сурyанегара, Јосе; МацГоwан, Гуy Г.; Поповић, Дејана; Грбовић, Миљан; Окwосе, Ндука; Цассидy, Сопхие; Нинковић, Владан; Јаковљевић, Ђорђе Г.;
dc.citation.volume56
dc.citation.issue3
dc.citation.spage321
dc.citation.epage329
dc.citation.other56(3): 321-329
dc.citation.rankM22
dc.identifier.wos000459478700007
dc.identifier.doi10.1007/s00592-018-1245-5
dc.identifier.pmid30387015
dc.identifier.scopus2-s2.0-85055999953
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1869/3301.pdf
dc.identifier.rcubconv_4323
dc.type.versionpublishedVersion


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