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dc.creatorĐekić, Ljiljana
dc.creatorMartinović, Martina
dc.creatorDobričić, Vladimir
dc.creatorČalija, Bojan
dc.creatorMedarević, Đorđe
dc.creatorPrimorac, Marija
dc.date.accessioned2019-09-02T12:10:05Z
dc.date.available2019-09-02T12:10:05Z
dc.date.issued2019
dc.identifier.issn0022-3549
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3305
dc.description.abstractThe study is focused on formulation of biocompatible hydrogels with a poorly soluble drug ibuprofen (5%) and comprehensive evaluation and comparison of effect of different bioadhesive polymers on their suitability for application on skin, physical stability during the accelerated and natural aging tests (by performing centrifugation test, light microscopy, differential scanning calorimetry, rheological and pH measurements), and in vitro drug release kinetics. Hydrogels, formulated with xanthan gum 1% (XIB), sodium carboxymethylcellulose 5% (CMCIB), poloxamer 407 16% (PIB), and carbomer 1% (KIB), were soft pseudoplastic semisolids with thixotropy and biocompatible pH. The type of the polymer significantly affected apparent viscosity of the hydrogels and miscibility rate with artificial sweat, their physical stability, and shape, size, and aggregation of the drug crystals and degree of crystallization. The drug release in all investigated hydrogels was diffusion-controlled in accordance with the Higuchi model and sustained for 12 h, with the drug release rate and the amount of drug released depended on the polymer. The described formulation approach enabled discrimination of the hydrogels with unsatisfactory application properties (CMCIB) and physical stability (KIB), and selection of the hydrogel with promising characteristics in terms of all investigated aspects (XIB) which could be considered for further evaluation.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.subjectbiocompatible hydrogelsen
dc.subjectxanthan gumen
dc.subjectsodium carboxymethylcelluloseen
dc.subjectcarbomeren
dc.subjectpoloxamer 407en
dc.subjectibuprofenen
dc.titleComparison of the Effect of Bioadhesive Polymers on Stability and Drug Release Kinetics of Biocompatible Hydrogels for Topical Application of Ibuprofenen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДобричић, Владимир; Приморац, Марија; Чалија, Бојан; Медаревић, Ђорђе; Мартиновић, Мартина; Ђекић, Љиљана;
dc.citation.volume108
dc.citation.issue3
dc.citation.spage1326
dc.citation.epage1333
dc.citation.other108(3): 1326-1333
dc.citation.rankM22
dc.identifier.wos000460009900030
dc.identifier.doi10.1016/j.xphs.2018.10.054
dc.identifier.pmid30395827
dc.identifier.scopus2-s2.0-85058561248
dc.identifier.rcubconv_4327
dc.type.versionpublishedVersion


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