FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C

Authorized Users Only
2019
Authors
Klisić, Aleksandra
Kavarić, Nebojša
Soldatović, Ivan
Ninić, Ana
Kotur-Stevuljević, Jelena
Article (Published version)
Metadata
Show full item record
Abstract
Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation leve...l and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.

Keywords:
cystatin C / metabolic syndrome / postmenopausal / retinol-binding protein 4
Source:
Journal of Laboratory Medicine, 2019, 43, 1, 29-34
Publisher:
  • Walter de Gruyter Gmbh, Berlin
Funding / projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1515/labmed-2018-0325

ISSN: 2567-9430

WoS: 000460105600005

Scopus: 2-s2.0-85062660682
[ Google Scholar ]
4
4
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3306
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Soldatović, Ivan
AU  - Ninić, Ana
AU  - Kotur-Stevuljević, Jelena
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3306
AB  - Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p  lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Journal of Laboratory Medicine
T1  - Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
VL  - 43
IS  - 1
SP  - 29
EP  - 34
DO  - 10.1515/labmed-2018-0325
ER  - 
@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Ninić, Ana and Kotur-Stevuljević, Jelena",
year = "2019",
abstract = "Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p  lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Journal of Laboratory Medicine",
title = "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C",
volume = "43",
number = "1",
pages = "29-34",
doi = "10.1515/labmed-2018-0325"
}
Klisić, A., Kavarić, N., Soldatović, I., Ninić, A.,& Kotur-Stevuljević, J.. (2019). Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 43(1), 29-34.
https://doi.org/10.1515/labmed-2018-0325
Klisić A, Kavarić N, Soldatović I, Ninić A, Kotur-Stevuljević J. Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine. 2019;43(1):29-34.
doi:10.1515/labmed-2018-0325 .
Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Ninić, Ana, Kotur-Stevuljević, Jelena, "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C" in Journal of Laboratory Medicine, 43, no. 1 (2019):29-34,
https://doi.org/10.1515/labmed-2018-0325 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB