Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C
Abstract
Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation leve...l and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.
Keywords:
cystatin C / metabolic syndrome / postmenopausal / retinol-binding protein 4Source:
Journal of Laboratory Medicine, 2019, 43, 1, 29-34Publisher:
- Walter de Gruyter Gmbh, Berlin
Funding / projects:
DOI: 10.1515/labmed-2018-0325
ISSN: 2567-9430
WoS: 000460105600005
Scopus: 2-s2.0-85062660682
Collections
Institution/Community
PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kavarić, Nebojša AU - Soldatović, Ivan AU - Ninić, Ana AU - Kotur-Stevuljević, Jelena PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3306 AB - Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women. PB - Walter de Gruyter Gmbh, Berlin T2 - Journal of Laboratory Medicine T1 - Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C VL - 43 IS - 1 SP - 29 EP - 34 DO - 10.1515/labmed-2018-0325 ER -
@article{ author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Ninić, Ana and Kotur-Stevuljević, Jelena", year = "2019", abstract = "Background: Retinol-binding protein 4 (RBP4) and cystatin C are regarded as novel metabolic risk markers. Therefore, we aimed to examine which one of these biomarkers better correlates with metabolic syndrome (MetS) in a cohort of postmenopausal women. Methods: A total of 129 postmenopausal women (among which 62 women had MetS) were recruited in this cross-sectional study. MetS was diagnosed according to the International Diabetes Federation criteria. Results: Cystatin C and RBP4 levels were significantly higher in women with MetS, compared to those without MetS (p = 0.011 vs. p lt 0.001, respectively). A significant difference in the proportion of women with and without MetS across cystatin C and RBP4 quartiles was observed (chi(2) = 5.1, p = 0.025, and chi(2) =11.1, p = 0.001, respectively). Logistic regression analysis revealed a borderline significant relationship between cystatin C and MetS (p = 0.066), but this significance disappeared after adjustment for age, inflammation level and duration of menopause (p = 0.221). On the contrary, a significant relationship between RBP4 and MetS was observed not only without adjustment (p = 0.009), but also even after adjustment for age, inflammation level and duration of menopause (p= 0.006). Conclusions: RBP4 better correlates with MetS than cystatin C in postmenopausal women.", publisher = "Walter de Gruyter Gmbh, Berlin", journal = "Journal of Laboratory Medicine", title = "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C", volume = "43", number = "1", pages = "29-34", doi = "10.1515/labmed-2018-0325" }
Klisić, A., Kavarić, N., Soldatović, I., Ninić, A.,& Kotur-Stevuljević, J.. (2019). Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine Walter de Gruyter Gmbh, Berlin., 43(1), 29-34. https://doi.org/10.1515/labmed-2018-0325
Klisić A, Kavarić N, Soldatović I, Ninić A, Kotur-Stevuljević J. Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C. in Journal of Laboratory Medicine. 2019;43(1):29-34. doi:10.1515/labmed-2018-0325 .
Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Ninić, Ana, Kotur-Stevuljević, Jelena, "Retinol-binding protein 4 better correlates with metabolic syndrome than cystatin C" in Journal of Laboratory Medicine, 43, no. 1 (2019):29-34, https://doi.org/10.1515/labmed-2018-0325 . .