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Novel composite zinc-alginate hydrogels with activated charcoal aimed for potential applications in multifunctional primary wound dressings

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2019
3306.pdf (668.3Kb)
Authors
Osmokrović, Andrea
Jančić, Ivan
Janković-Castvan, Ivona
Petrović, Predrag
Milenković, Marina
Obradović, Bojana
Article (Published version)
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Abstract
Composites based on Zn-alginate hydrogels in the form of beads were produced by extrusion of a suspension containing 0.5 % w/w of alginate and 20 % w/w of activated charcoal (AC) with the intent to simultaneously release two active agents, Zn2+ and AC particles, in a physiological-like environment. The obtained composite beads were analyzed by FE-SEM and characterized regarding textural parameters, as well as Zn2+ and AC release kinetics in the physiological saline solution. Zn(2+)ions were quickly released reaching the equilibrium concentration within the first hour in the contrary to the release of AC particles, which was described by internal diffusion with the apparent diffusion coefficient of approximately 10(-13) m(2) s(-1). Potential functionality of the obtained beads was evaluated regarding antibacterial activity in suspensions of the standard bacterial strain Escherichia coli 25922. The observed strong bactericidal effects were related to the quick release of Zn2+ that was no...t affected by AC. Thus, taking into account results of this study, as well as high sorption capacity of alginate hydrogel, efficiency of AC to adsorb malodor and tissue degradation products and positive effects of Zn2+ on wound healing, the obtained composites have shown promising potentials for applications as multifunctional wound dressings.

Keywords:
zinc ions / activated charcoal / alginate hydrogels / antibacterial activity / wound dressing
Source:
Hemijska industrija, 2019, 73, 1, 37-46
Publisher:
  • Savez hemijskih inženjera, Beograd
Projects:
  • Synthesis, processing and applications of nanostructured multifunctional materials with defined properties (RS-45019)

DOI: 10.2298/HEMIND180629003O

ISSN: 0367-598X

WoS: 000460129400004

Scopus: 2-s2.0-85064243986
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3308
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Institution
Pharmacy

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