Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients

2019
Authors
Radović, MinaBojić, Suzana
Kotur-Stevuljević, Jelena

Lezaić, Višnja
Milicić, Biljana
Velinović, Miloš
Karan, Radmila
Simić-Ogrizović, Sanja

Article (Published version)

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Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest ...odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.
Keywords:
acute kidney injury / cardiac surgery / Kidney Injury Molecule-1 / lactate / Neutrophil Gelatinase-Associated LipocalinSource:
Journal of Medical Biochemistry, 2019, 38, 2, 118-125Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
DOI: 10.2478/jomb-2018-0018
ISSN: 1452-8258
PubMed: 30867639
WoS: 000460757200002
Scopus: 2-s2.0-85049165398
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Institution/Community
PharmacyTY - JOUR AU - Radović, Mina AU - Bojić, Suzana AU - Kotur-Stevuljević, Jelena AU - Lezaić, Višnja AU - Milicić, Biljana AU - Velinović, Miloš AU - Karan, Radmila AU - Simić-Ogrizović, Sanja PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3311 AB - Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients VL - 38 IS - 2 SP - 118 EP - 125 DO - 10.2478/jomb-2018-0018 ER -
@article{ author = "Radović, Mina and Bojić, Suzana and Kotur-Stevuljević, Jelena and Lezaić, Višnja and Milicić, Biljana and Velinović, Miloš and Karan, Radmila and Simić-Ogrizović, Sanja", year = "2019", abstract = "Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients", volume = "38", number = "2", pages = "118-125", doi = "10.2478/jomb-2018-0018" }
Radović, M., Bojić, S., Kotur-Stevuljević, J., Lezaić, V., Milicić, B., Velinović, M., Karan, R.,& Simić-Ogrizović, S.. (2019). Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(2), 118-125. https://doi.org/10.2478/jomb-2018-0018
Radović M, Bojić S, Kotur-Stevuljević J, Lezaić V, Milicić B, Velinović M, Karan R, Simić-Ogrizović S. Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry. 2019;38(2):118-125. doi:10.2478/jomb-2018-0018 .
Radović, Mina, Bojić, Suzana, Kotur-Stevuljević, Jelena, Lezaić, Višnja, Milicić, Biljana, Velinović, Miloš, Karan, Radmila, Simić-Ogrizović, Sanja, "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients" in Journal of Medical Biochemistry, 38, no. 2 (2019):118-125, https://doi.org/10.2478/jomb-2018-0018 . .