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dc.creatorRadović, Mina
dc.creatorBojić, Suzana
dc.creatorKotur-Stevuljević, Jelena
dc.creatorLezaić, Višnja
dc.creatorMilicić, Biljana
dc.creatorVelinović, Miloš
dc.creatorKaran, Radmila
dc.creatorSimić-Ogrizović, Sanja
dc.date.accessioned2019-09-02T12:10:13Z
dc.date.available2019-09-02T12:10:13Z
dc.date.issued2019
dc.identifier.issn1452-8258
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3311
dc.description.abstractBackground: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175089/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectacute kidney injuryen
dc.subjectcardiac surgeryen
dc.subjectKidney Injury Molecule-1en
dc.subjectlactateen
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen
dc.titleSerum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСимић-Огризовић, Сања; Милицић, Биљана; Каран, Радмила; Бојић, Сузана; Радовић, Мина; Лезаић, Вишња; Велиновић, Милош; Котур-Стевуљевић, Јелена;
dc.citation.volume38
dc.citation.issue2
dc.citation.spage118
dc.citation.epage125
dc.citation.other38(2): 118-125
dc.citation.rankM23
dc.identifier.wos000460757200002
dc.identifier.doi10.2478/jomb-2018-0018
dc.identifier.pmid30867639
dc.identifier.scopus2-s2.0-85049165398
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1876/3309.pdf
dc.type.versionpublishedVersion


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