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Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients
dc.creator | Radović, Mina | |
dc.creator | Bojić, Suzana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Lezaić, Višnja | |
dc.creator | Milicić, Biljana | |
dc.creator | Velinović, Miloš | |
dc.creator | Karan, Radmila | |
dc.creator | Simić-Ogrizović, Sanja | |
dc.date.accessioned | 2019-09-02T12:10:13Z | |
dc.date.available | 2019-09-02T12:10:13Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3311 | |
dc.description.abstract | Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI. UNGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uNGAL and KIM-1 levels compared to patients without CSA-AKI. Unlike uNGAL and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration >= 4 mmol/L carried dramatically higher risk for developing CSA-AKI (OR 6.3 [1.9-20.5]). Conclusions: Unlike uNGAL and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije, Beograd i Versita | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175089/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Medical Biochemistry | |
dc.subject | acute kidney injury | en |
dc.subject | cardiac surgery | en |
dc.subject | Kidney Injury Molecule-1 | en |
dc.subject | lactate | en |
dc.subject | Neutrophil Gelatinase-Associated Lipocalin | en |
dc.title | Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Симић-Огризовић, Сања; Милицић, Биљана; Каран, Радмила; Бојић, Сузана; Радовић, Мина; Лезаић, Вишња; Велиновић, Милош; Котур-Стевуљевић, Јелена; | |
dc.citation.volume | 38 | |
dc.citation.issue | 2 | |
dc.citation.spage | 118 | |
dc.citation.epage | 125 | |
dc.citation.other | 38(2): 118-125 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000460757200002 | |
dc.identifier.doi | 10.2478/jomb-2018-0018 | |
dc.identifier.pmid | 30867639 | |
dc.identifier.scopus | 2-s2.0-85049165398 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1876/3309.pdf | |
dc.type.version | publishedVersion |