Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing
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2019
Authors
Popović, Dejana
Guazzi, Marco
Jakovljević, Đorđe G.

Lasica, Ratko
Banović, Marko
Ostojić, Miodrag
Arena, Ross

Article (Published version)

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Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET pa...rameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p lt 0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.
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International Journal of Cardiology, 2019, 285, 11-13Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
DOI: 10.1016/j.ijcard.2019.03.012
ISSN: 0167-5273
PubMed: 30879940
WoS: 000464016000003
Scopus: 2-s2.0-85062809695
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PharmacyTY - JOUR AU - Popović, Dejana AU - Guazzi, Marco AU - Jakovljević, Đorđe G. AU - Lasica, Ratko AU - Banović, Marko AU - Ostojić, Miodrag AU - Arena, Ross PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3316 AB - Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p lt 0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE. PB - Elsevier Ireland Ltd, Clare T2 - International Journal of Cardiology T1 - Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing VL - 285 SP - 11 EP - 13 DO - 10.1016/j.ijcard.2019.03.012 ER -
@article{ author = "Popović, Dejana and Guazzi, Marco and Jakovljević, Đorđe G. and Lasica, Ratko and Banović, Marko and Ostojić, Miodrag and Arena, Ross", year = "2019", abstract = "Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p lt 0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.", publisher = "Elsevier Ireland Ltd, Clare", journal = "International Journal of Cardiology", title = "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing", volume = "285", pages = "11-13", doi = "10.1016/j.ijcard.2019.03.012" }
Popović, D., Guazzi, M., Jakovljević, Đ. G., Lasica, R., Banović, M., Ostojić, M.,& Arena, R.. (2019). Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology Elsevier Ireland Ltd, Clare., 285, 11-13. https://doi.org/10.1016/j.ijcard.2019.03.012
Popović D, Guazzi M, Jakovljević ĐG, Lasica R, Banović M, Ostojić M, Arena R. Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology. 2019;285:11-13. doi:10.1016/j.ijcard.2019.03.012 .
Popović, Dejana, Guazzi, Marco, Jakovljević, Đorđe G., Lasica, Ratko, Banović, Marko, Ostojić, Miodrag, Arena, Ross, "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing" in International Journal of Cardiology, 285 (2019):11-13, https://doi.org/10.1016/j.ijcard.2019.03.012 . .