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dc.creatorVujnović, Ivana
dc.creatorPilipović, Ivan
dc.creatorJasnić, Nebojša
dc.creatorPetrović, Raisa
dc.creatorBlagojević, Veljko
dc.creatorArsenović-Ranin, Nevena
dc.creatorStojić-Vukanić, Zorica
dc.creatorĐorđević, Jelena
dc.creatorLeposavić, Gordana
dc.date.accessioned2019-09-02T12:10:35Z
dc.date.available2019-09-02T12:10:35Z
dc.date.issued2019
dc.identifier.issn0008-8749
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3323
dc.description.abstractMales exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4 + T-cell (auto) immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (beta-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4 + T cells from female and male EAE rat draining lymph node (dLN) cell cultures was examined. Male rat dLNs exhibited higher noradrenaline concentration and frequency of beta(2)-adrenoceptor-expressing CD4 + T lymphocytes and antigen presenting cells. Propranolol, irrespective of exogenous noradrenaline presence, more prominently augmented IL-2 production and proliferation of CD4 + lymphocytes in male than female rat dLN cell cultures. In neuroantigen-stimulated dLN cells of both sexes propranolol increased IL-1 beta and IL-23/p19 expression and IL-17 + CD4 + cell frequency, but enhanced IL-17 production only in male rat CD4 + lymphocytes, thereby abrogating sexual dimorphism in IL-17 concentration observed in propranolol-free cultures. Thus, beta-adrenoceptor-mediated signalling may contribute to sex bias in rat IL-17-producing cell secretory capacity.en
dc.publisherAcademic Press Inc Elsevier Science, San Diego
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS//
dc.rightsrestrictedAccess
dc.sourceCellular Immunology
dc.subjectEAEen
dc.subjectNoradrenalineen
dc.subjectbeta-Adrenoceptoren
dc.subjectDraining lymph nodesen
dc.subjectCD4+cell proliferationen
dc.subjectTh17 differentiationen
dc.titleNoradrenaline through beta-adrenoceptor contributes to sexual dimorphism in primary CD4+T-cell response in DA rat EAE model?en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојић-Вуканић, Зорица; Лепосавић, Гордана; Aрсеновић-Ранин, Невена; Пилиповић, Иван; Благојевић, Вељко; Вујновић, Ивана; Петровић, Раиса; Јаснић, Небојша; Ђорђевић, Јелена;
dc.citation.volume336
dc.citation.spage48
dc.citation.epage57
dc.citation.other336: 48-57
dc.citation.rankM22
dc.identifier.wos000458018100007
dc.identifier.doi10.1016/j.cellimm.2018.12.009
dc.identifier.pmid30600100
dc.identifier.scopus2-s2.0-85059116104
dc.identifier.rcubconv_4313
dc.type.versionpublishedVersion


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