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Noradrenaline through beta-adrenoceptor contributes to sexual dimorphism in primary CD4+T-cell response in DA rat EAE model?
dc.creator | Vujnović, Ivana | |
dc.creator | Pilipović, Ivan | |
dc.creator | Jasnić, Nebojša | |
dc.creator | Petrović, Raisa | |
dc.creator | Blagojević, Veljko | |
dc.creator | Arsenović-Ranin, Nevena | |
dc.creator | Stojić-Vukanić, Zorica | |
dc.creator | Đorđević, Jelena | |
dc.creator | Leposavić, Gordana | |
dc.date.accessioned | 2019-09-02T12:10:35Z | |
dc.date.available | 2019-09-02T12:10:35Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0008-8749 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3323 | |
dc.description.abstract | Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4 + T-cell (auto) immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (beta-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4 + T cells from female and male EAE rat draining lymph node (dLN) cell cultures was examined. Male rat dLNs exhibited higher noradrenaline concentration and frequency of beta(2)-adrenoceptor-expressing CD4 + T lymphocytes and antigen presenting cells. Propranolol, irrespective of exogenous noradrenaline presence, more prominently augmented IL-2 production and proliferation of CD4 + lymphocytes in male than female rat dLN cell cultures. In neuroantigen-stimulated dLN cells of both sexes propranolol increased IL-1 beta and IL-23/p19 expression and IL-17 + CD4 + cell frequency, but enhanced IL-17 production only in male rat CD4 + lymphocytes, thereby abrogating sexual dimorphism in IL-17 concentration observed in propranolol-free cultures. Thus, beta-adrenoceptor-mediated signalling may contribute to sex bias in rat IL-17-producing cell secretory capacity. | en |
dc.publisher | Academic Press Inc Elsevier Science, San Diego | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175050/RS// | |
dc.rights | restrictedAccess | |
dc.source | Cellular Immunology | |
dc.subject | EAE | en |
dc.subject | Noradrenaline | en |
dc.subject | beta-Adrenoceptor | en |
dc.subject | Draining lymph nodes | en |
dc.subject | CD4+cell proliferation | en |
dc.subject | Th17 differentiation | en |
dc.title | Noradrenaline through beta-adrenoceptor contributes to sexual dimorphism in primary CD4+T-cell response in DA rat EAE model? | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Стојић-Вуканић, Зорица; Лепосавић, Гордана; Aрсеновић-Ранин, Невена; Пилиповић, Иван; Благојевић, Вељко; Вујновић, Ивана; Петровић, Раиса; Јаснић, Небојша; Ђорђевић, Јелена; | |
dc.citation.volume | 336 | |
dc.citation.spage | 48 | |
dc.citation.epage | 57 | |
dc.citation.other | 336: 48-57 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000458018100007 | |
dc.identifier.doi | 10.1016/j.cellimm.2018.12.009 | |
dc.identifier.pmid | 30600100 | |
dc.identifier.scopus | 2-s2.0-85059116104 | |
dc.type.version | publishedVersion |