Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control
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2019
Authors
Bojanin, DraganaVekić, Jelena
Milenković, Tatjana
Vuković, Rade
Zeljković, Aleksandra
Stefanović, Aleksandra
Janać, Jelena
Ivanišević, Jasmina
Mitrović, Katarina
Miljković, Milica
Spasojević-Kalimanovska, Vesna
Article (Published version)
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Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p lt 0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid paramet...ers only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p lt 0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p lt 0.001), but negatively with HDL size (p lt 0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.
Keywords:
PCSK9 / Small / Dense LDL / HDL / Glucoregulation / Dyslipidemia / Type 1 diabetesSource:
Atherosclerosis, 2019, 280, 14-20Publisher:
- Elsevier Ireland Ltd, Clare
Funding / projects:
DOI: 10.1016/j.atherosclerosis.2018.11.020
ISSN: 0021-9150
PubMed: 30453116
WoS: 000456421100003
Scopus: 2-s2.0-85056660723
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PharmacyTY - JOUR AU - Bojanin, Dragana AU - Vekić, Jelena AU - Milenković, Tatjana AU - Vuković, Rade AU - Zeljković, Aleksandra AU - Stefanović, Aleksandra AU - Janać, Jelena AU - Ivanišević, Jasmina AU - Mitrović, Katarina AU - Miljković, Milica AU - Spasojević-Kalimanovska, Vesna PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3326 AB - Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p lt 0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p lt 0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p lt 0.001), but negatively with HDL size (p lt 0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM. PB - Elsevier Ireland Ltd, Clare T2 - Atherosclerosis T1 - Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control VL - 280 SP - 14 EP - 20 DO - 10.1016/j.atherosclerosis.2018.11.020 ER -
@article{ author = "Bojanin, Dragana and Vekić, Jelena and Milenković, Tatjana and Vuković, Rade and Zeljković, Aleksandra and Stefanović, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Mitrović, Katarina and Miljković, Milica and Spasojević-Kalimanovska, Vesna", year = "2019", abstract = "Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p lt 0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p lt 0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p lt 0.001), but negatively with HDL size (p lt 0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Atherosclerosis", title = "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control", volume = "280", pages = "14-20", doi = "10.1016/j.atherosclerosis.2018.11.020" }
Bojanin, D., Vekić, J., Milenković, T., Vuković, R., Zeljković, A., Stefanović, A., Janać, J., Ivanišević, J., Mitrović, K., Miljković, M.,& Spasojević-Kalimanovska, V.. (2019). Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis Elsevier Ireland Ltd, Clare., 280, 14-20. https://doi.org/10.1016/j.atherosclerosis.2018.11.020
Bojanin D, Vekić J, Milenković T, Vuković R, Zeljković A, Stefanović A, Janać J, Ivanišević J, Mitrović K, Miljković M, Spasojević-Kalimanovska V. Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis. 2019;280:14-20. doi:10.1016/j.atherosclerosis.2018.11.020 .
Bojanin, Dragana, Vekić, Jelena, Milenković, Tatjana, Vuković, Rade, Zeljković, Aleksandra, Stefanović, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Mitrović, Katarina, Miljković, Milica, Spasojević-Kalimanovska, Vesna, "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control" in Atherosclerosis, 280 (2019):14-20, https://doi.org/10.1016/j.atherosclerosis.2018.11.020 . .