Nitric oxide products are not associated with metabolic syndrome

2019
Authors
Klisić, Aleksandra
Kocić, Gordana
Kavarić, Nebojša
Pavlović, Radmila
Soldatović, Ivan
Ninić, Ana

Article (Published version)

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Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO ...(OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.
Keywords:
inflammation / metabolic syndrome / obesity / oxidative stressSource:
Journal of Medical Biochemistry, 2019, 38, 3, 361-367Publisher:
- Društvo medicinskih biohemičara Srbije, Beograd i Versita
Funding / projects:
DOI: 10.2478/jomb-2018-0035
ISSN: 1452-8258
PubMed: 31156347
WoS: 000468363100014
Scopus: 2-s2.0-85060006611
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Institution/Community
PharmacyTY - JOUR AU - Klisić, Aleksandra AU - Kocić, Gordana AU - Kavarić, Nebojša AU - Pavlović, Radmila AU - Soldatović, Ivan AU - Ninić, Ana PY - 2019 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3342 AB - Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS. PB - Društvo medicinskih biohemičara Srbije, Beograd i Versita T2 - Journal of Medical Biochemistry T1 - Nitric oxide products are not associated with metabolic syndrome VL - 38 IS - 3 SP - 361 EP - 367 DO - 10.2478/jomb-2018-0035 ER -
@article{ author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Pavlović, Radmila and Soldatović, Ivan and Ninić, Ana", year = "2019", abstract = "Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.", publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita", journal = "Journal of Medical Biochemistry", title = "Nitric oxide products are not associated with metabolic syndrome", volume = "38", number = "3", pages = "361-367", doi = "10.2478/jomb-2018-0035" }
Klisić, A., Kocić, G., Kavarić, N., Pavlović, R., Soldatović, I.,& Ninić, A.. (2019). Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 361-367. https://doi.org/10.2478/jomb-2018-0035
Klisić A, Kocić G, Kavarić N, Pavlović R, Soldatović I, Ninić A. Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry. 2019;38(3):361-367. doi:10.2478/jomb-2018-0035 .
Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Pavlović, Radmila, Soldatović, Ivan, Ninić, Ana, "Nitric oxide products are not associated with metabolic syndrome" in Journal of Medical Biochemistry, 38, no. 3 (2019):361-367, https://doi.org/10.2478/jomb-2018-0035 . .