Show simple item record

dc.creatorKlisić, Aleksandra
dc.creatorKocić, Gordana
dc.creatorKavarić, Nebojša
dc.creatorPavlović, Radmila
dc.creatorSoldatović, Ivan
dc.creatorNinić, Ana
dc.date.accessioned2019-09-02T12:11:05Z
dc.date.available2019-09-02T12:11:05Z
dc.date.issued2019
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3342
dc.description.abstractBackground: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectinflammationen
dc.subjectmetabolic syndromeen
dc.subjectobesityen
dc.subjectoxidative stressen
dc.titleNitric oxide products are not associated with metabolic syndromeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКоцић, Гордана; Каварић, Небојша; Нинић, Aна; Солдатовић, Иван; Клисић, Aлександра; Павловић, Радмила;
dc.citation.volume38
dc.citation.issue3
dc.citation.spage361
dc.citation.epage367
dc.citation.other38(3): 361-367
dc.citation.rankM23
dc.identifier.wos000468363100014
dc.identifier.doi10.2478/jomb-2018-0035
dc.identifier.pmid31156347
dc.identifier.scopus2-s2.0-85060006611
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1907/3340.pdf
dc.identifier.rcubconv_4383
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record