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dc.creatorKovačević, Tijana
dc.creatorMiljković, Branislava
dc.creatorMikov, Momir
dc.creatorStojisavljević-Satara, Svjetlana
dc.creatorDragić, Sasa
dc.creatorMomcicević, Danica
dc.creatorKovacević, Peđa
dc.date.accessioned2019-09-02T12:11:10Z
dc.date.available2019-09-02T12:11:10Z
dc.date.issued2019
dc.identifier.issn1559-3258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3345
dc.description.abstractPurpose: To determine whether severe hypoalbuminemia ( lt 25 mg/L) has a significant effect on serum levels of vancomycin and whether it can effect vancomycin dosage regimen and the loading dose administration. Material and Methods: Prospective, cohort, and a single-center study included 61 patients whose vancomycin serum levels were measured in steady state. Vancomycin trough levels (C-min) that were in the range 15 to 20 mu g/mL were considered therapeutic and trough levels higher than 15 mu g/mL were considered potentially nephrotoxic. Results: In the group of patients with severe hypoalbuminemia, C-min was significantly higher compared to the those with nonsevere hypoalbuminemia (>25 mg/L; 23.04 [19.14] vs 13.28 [11.28], P = .01). In the group of patients who received the vancomycin loading dose of 2 g, C-min was significantly higher in patients with severe hypoalbuminemia compared to the patients with nonsevere hypoalbuminemia (34.52 [25.93] vs 15.37 [10.48], P = .04). Conclusion: In critically ill septic patients with severe hypoalbuminemia, there is a high probability that the loading dose of vancomycin is not necessary since it is associated with potentially toxic vancomycin C-min, while in the patients with nonsevere hypoalbuminemia the loading dose may be necessary to achieving therapeutic C-min.en
dc.publisherSage Publications Inc, Thousand Oaks
dc.rightsopenAccess
dc.sourceDose-Response
dc.subjectsevere hypoalbuminemiaen
dc.subjectvancomycinen
dc.subjecttherapeutic drug monitoringen
dc.subjectsepsisen
dc.subjectcritical illnessen
dc.titleThe Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countriesen
dc.typearticle
dc.rights.licenseBY-NC
dcterms.abstractСтојисављевић-Сатара, Свјетлана; Миков, Момир; Драгић, Саса; Миљковић, Бранислава; Момцицевић, Даница; Ковацевић, Пеђа; Ковачевић, Тијана;
dc.citation.volume17
dc.citation.issue2
dc.citation.other17(2): -
dc.citation.rankM22
dc.identifier.wos000468927300001
dc.identifier.doi10.1177/1559325819850419
dc.identifier.pmid31205457
dc.identifier.scopus2-s2.0-85067646752
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1910/3343.pdf
dc.identifier.rcubconv_4386
dc.type.versionpublishedVersion


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