dc.creator | Kovačević, Tijana | |
dc.creator | Miljković, Branislava | |
dc.creator | Mikov, Momir | |
dc.creator | Stojisavljević-Satara, Svjetlana | |
dc.creator | Dragić, Sasa | |
dc.creator | Momcicević, Danica | |
dc.creator | Kovacević, Peđa | |
dc.date.accessioned | 2019-09-02T12:11:10Z | |
dc.date.available | 2019-09-02T12:11:10Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1559-3258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3345 | |
dc.description.abstract | Purpose: To determine whether severe hypoalbuminemia ( lt 25 mg/L) has a significant effect on serum levels of vancomycin and whether it can effect vancomycin dosage regimen and the loading dose administration. Material and Methods: Prospective, cohort, and a single-center study included 61 patients whose vancomycin serum levels were measured in steady state. Vancomycin trough levels (C-min) that were in the range 15 to 20 mu g/mL were considered therapeutic and trough levels higher than 15 mu g/mL were considered potentially nephrotoxic. Results: In the group of patients with severe hypoalbuminemia, C-min was significantly higher compared to the those with nonsevere hypoalbuminemia (>25 mg/L; 23.04 [19.14] vs 13.28 [11.28], P = .01). In the group of patients who received the vancomycin loading dose of 2 g, C-min was significantly higher in patients with severe hypoalbuminemia compared to the patients with nonsevere hypoalbuminemia (34.52 [25.93] vs 15.37 [10.48], P = .04). Conclusion: In critically ill septic patients with severe hypoalbuminemia, there is a high probability that the loading dose of vancomycin is not necessary since it is associated with potentially toxic vancomycin C-min, while in the patients with nonsevere hypoalbuminemia the loading dose may be necessary to achieving therapeutic C-min. | en |
dc.publisher | Sage Publications Inc, Thousand Oaks | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Dose-Response | |
dc.subject | severe hypoalbuminemia | en |
dc.subject | vancomycin | en |
dc.subject | therapeutic drug monitoring | en |
dc.subject | sepsis | en |
dc.subject | critical illness | en |
dc.title | The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dcterms.abstract | Стојисављевић-Сатара, Свјетлана; Миков, Момир; Драгић, Саса; Миљковић, Бранислава; Момцицевић, Даница; Ковацевић, Пеђа; Ковачевић, Тијана; | |
dc.citation.volume | 17 | |
dc.citation.issue | 2 | |
dc.citation.other | 17(2): - | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000468927300001 | |
dc.identifier.doi | 10.1177/1559325819850419 | |
dc.identifier.pmid | 31205457 | |
dc.identifier.scopus | 2-s2.0-85067646752 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1910/3343.pdf | |
dc.type.version | publishedVersion | |