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dc.creatorĐorđević, Vladimir
dc.creatorWallace, David
dc.creatorSchweitzer, Amie
dc.creatorBoricić, Novica
dc.creatorKnežević, Đorđe
dc.creatorMatić, Slavko
dc.creatorGrubor, Nikola
dc.creatorKerkez, Mirko
dc.creatorRadenković, Dejan
dc.creatorBulat, Zorica
dc.creatorAntonijević, Biljana
dc.creatorMatović, Vesna
dc.creatorBuha, Aleksandra
dc.date.accessioned2019-09-02T12:11:11Z
dc.date.available2019-09-02T12:11:11Z
dc.date.issued2019
dc.identifier.issn0160-4120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3346
dc.description.abstractAlthough profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w) and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91-8.50) and 3.44 (95% CI 1.19-9.95) in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.sourceEnvironment International
dc.subjectPancreatic canceren
dc.subjectCadmiumen
dc.subjectCarcinogenesisen
dc.subjectRisk factorsen
dc.titleEnvironmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂорђевић, Владимир; Буха, Aлександра; Булат, Зорица; Матовић, Весна; Aнтонијевић, Биљана; Раденковић, Дејан; Грубор, Никола; Матић, Славко; Кнежевић, Ђорђе; Керкез, Мирко; Борицић, Новица; Wаллаце, Давид; Сцхwеитзер, Aмие;
dc.citation.volume128
dc.citation.spage353
dc.citation.epage361
dc.citation.other128: 353-361
dc.citation.rankaM21
dc.identifier.wos000467938500037
dc.identifier.doi10.1016/j.envint.2019.04.048
dc.identifier.pmid31078004
dc.identifier.scopus2-s2.0-85065160440
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1911/3344.pdf
dc.identifier.rcubconv_4374
dc.type.versionpublishedVersion


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