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dc.creatorVekić, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorStefanović, Aleksandra
dc.creatorJelić-Ivanović, Zorana
dc.creatorSpasojević-Kalimanovska, Vesna
dc.date.accessioned2019-09-02T12:11:18Z
dc.date.available2019-09-02T12:11:18Z
dc.date.issued2019
dc.identifier.issn0026-0495
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3349
dc.description.abstractObesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines. However, recent evidence suggests that obesity-induced dyslipidemia is not a unique pathophysiological entity, but rather has distinct characteristics depending on many individual factors. In line with that, in a subgroup of metabolically healthy obese (MHO) individuals, dyslipidemia is less prominent or even absent. In this review, we will address the main characteristics of dyslipidemia and mechanisms that induce its development in obesity. The fields, which should be further investigated to expand our knowledge on obesity-related dyslipidemia and potentially yield new strategies for prevention and management of cardiometabolic risk, will be highlighted. Also, we will discuss recent findings on novel lipid biomarkers in obesity, in particular proprotein convertase subtilisin/kexin type 9 (PCSK9), as the key molecule that regulates metabolism of low-density lipoproteins (LDL), and sphingosine-1-phosphate (S1P), as one of the most important mediators of high-density lipoprotein (HDL) partides function. Special attention will be given to microRNAs and their potential use as biomarkers of obesity-associated dyslipidemia.en
dc.publisherW B Saunders Co-Elsevier Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceMetabolism-Clinical and Experimental
dc.subjectInsulin resistanceen
dc.subjectAdipokinesen
dc.subjectVitamin Den
dc.subjectSmall, dense LDLen
dc.subjectPCSK9en
dc.subjectSphingosine-1-phosphateen
dc.subjectMicroRNAen
dc.titleObesity and dyslipidemiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Зељковић, Aлександра; Векић, Јелена; Стефановић, Aлександра;
dc.citation.volume92
dc.citation.spage71
dc.citation.epage81
dc.citation.other92: 71-81
dc.citation.rankaM21
dc.identifier.wos000470303900008
dc.identifier.doi10.1016/j.metabol.2018.11.005
dc.identifier.pmid30447223
dc.identifier.scopus2-s2.0-85058403746
dc.identifier.rcubconv_4393
dc.type.versionpublishedVersion


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