Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age
Само за регистроване кориснике
2002
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic ly...mphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions.
Извор:
Mechanisms of Ageing and Development, 2002, 123, 4, 401-411Издавач:
- Elsevier Sci Ireland Ltd, Clare
DOI: 10.1016/S0047-6374(01)00399-2
ISSN: 0047-6374
PubMed: 11744050
WoS: 000177125000013
Scopus: 2-s2.0-0036138232
Институција/група
PharmacyTY - JOUR AU - Leposavić, Gordana AU - Pejčić-Karapetrović, Branka AU - Kosec, Duško PY - 2002 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/335 AB - In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions. PB - Elsevier Sci Ireland Ltd, Clare T2 - Mechanisms of Ageing and Development T1 - Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age VL - 123 IS - 4 SP - 401 EP - 411 DO - 10.1016/S0047-6374(01)00399-2 ER -
@article{ author = "Leposavić, Gordana and Pejčić-Karapetrović, Branka and Kosec, Duško", year = "2002", abstract = "In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions.", publisher = "Elsevier Sci Ireland Ltd, Clare", journal = "Mechanisms of Ageing and Development", title = "Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age", volume = "123", number = "4", pages = "401-411", doi = "10.1016/S0047-6374(01)00399-2" }
Leposavić, G., Pejčić-Karapetrović, B.,& Kosec, D.. (2002). Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age. in Mechanisms of Ageing and Development Elsevier Sci Ireland Ltd, Clare., 123(4), 401-411. https://doi.org/10.1016/S0047-6374(01)00399-2
Leposavić G, Pejčić-Karapetrović B, Kosec D. Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age. in Mechanisms of Ageing and Development. 2002;123(4):401-411. doi:10.1016/S0047-6374(01)00399-2 .
Leposavić, Gordana, Pejčić-Karapetrović, Branka, Kosec, Duško, "Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age" in Mechanisms of Ageing and Development, 123, no. 4 (2002):401-411, https://doi.org/10.1016/S0047-6374(01)00399-2 . .