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Alterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different age

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2002
Authors
Leposavić, Gordana
Pejčić-Karapetrović, Branka
Kosec, Duško
Article (Published version)
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Abstract
In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic ly...mphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions.

Source:
Mechanisms of Ageing and Development, 2002, 123, 4, 401-411
Publisher:
  • Elsevier Sci Ireland Ltd, Clare

DOI: 10.1016/S0047-6374(01)00399-2

ISSN: 0047-6374

PubMed: 11744050

WoS: 000177125000013

Scopus: 2-s2.0-0036138232
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/335
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Pharmacy

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