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Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa

Authorized Users Only
2019
Authors
Usjak, Dušan
Ivković, Branka
Božić, Dragana
Bošković, Lidija
Milenković, Marina
Article (Published version)
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Abstract
Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. The aim of this study was to examine effectiveness of four newly-synthesized chalcones against the multiresistant clinical strains of A. baumannii and P. aeruginosa. Antibacterial activity of chalcones was investigated with broth-microdilution test and time-dependent killing assay. Synergistic effects of tested compounds with antibiotics (meropenem, amikacin and ciprofloxacin) were determined by checkerboard assay. The effects of chalcones on expression of virulence factors in P. aeruginosa (pyocyanin... production, swimming and swarming motility) and A. baumannii (twitching and surface-associated motility), along with their biofilm production, were also examined. The obtained results indicate substantial antimicrobial activity of the tested chalcones (MICs = 100-175 mu g/mL) and several synergistic interactions with antibiotics, as well as notable reduction in expression of all investigated virulence factors. These promising results may constitute a good basis for further research.

Keywords:
Chalcones / Acinetobacter baumannii / Pseudomonas aeruginosa / Biofilm / Motility
Source:
Microbial Pathogenesis, 2019, 131, 186-196
Publisher:
  • Academic Press Ltd- Elsevier Science Ltd, London

DOI: 10.1016/j.micpath.2019.04.015

ISSN: 0882-4010

PubMed: 30980878

WoS: 000471208000026

Scopus: 2-s2.0-85064077948
[ Google Scholar ]
21
13
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3351
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Usjak, Dušan
AU  - Ivković, Branka
AU  - Božić, Dragana
AU  - Bošković, Lidija
AU  - Milenković, Marina
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3351
AB  - Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. The aim of this study was to examine effectiveness of four newly-synthesized chalcones against the multiresistant clinical strains of A. baumannii and P. aeruginosa. Antibacterial activity of chalcones was investigated with broth-microdilution test and time-dependent killing assay. Synergistic effects of tested compounds with antibiotics (meropenem, amikacin and ciprofloxacin) were determined by checkerboard assay. The effects of chalcones on expression of virulence factors in P. aeruginosa (pyocyanin production, swimming and swarming motility) and A. baumannii (twitching and surface-associated motility), along with their biofilm production, were also examined. The obtained results indicate substantial antimicrobial activity of the tested chalcones (MICs = 100-175 mu g/mL) and several synergistic interactions with antibiotics, as well as notable reduction in expression of all investigated virulence factors. These promising results may constitute a good basis for further research.
PB  - Academic Press Ltd- Elsevier Science Ltd, London
T2  - Microbial Pathogenesis
T1  - Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa
VL  - 131
SP  - 186
EP  - 196
DO  - 10.1016/j.micpath.2019.04.015
ER  - 
@article{
author = "Usjak, Dušan and Ivković, Branka and Božić, Dragana and Bošković, Lidija and Milenković, Marina",
year = "2019",
abstract = "Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. The aim of this study was to examine effectiveness of four newly-synthesized chalcones against the multiresistant clinical strains of A. baumannii and P. aeruginosa. Antibacterial activity of chalcones was investigated with broth-microdilution test and time-dependent killing assay. Synergistic effects of tested compounds with antibiotics (meropenem, amikacin and ciprofloxacin) were determined by checkerboard assay. The effects of chalcones on expression of virulence factors in P. aeruginosa (pyocyanin production, swimming and swarming motility) and A. baumannii (twitching and surface-associated motility), along with their biofilm production, were also examined. The obtained results indicate substantial antimicrobial activity of the tested chalcones (MICs = 100-175 mu g/mL) and several synergistic interactions with antibiotics, as well as notable reduction in expression of all investigated virulence factors. These promising results may constitute a good basis for further research.",
publisher = "Academic Press Ltd- Elsevier Science Ltd, London",
journal = "Microbial Pathogenesis",
title = "Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa",
volume = "131",
pages = "186-196",
doi = "10.1016/j.micpath.2019.04.015"
}
Usjak, D., Ivković, B., Božić, D., Bošković, L.,& Milenković, M.. (2019). Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa. in Microbial Pathogenesis
Academic Press Ltd- Elsevier Science Ltd, London., 131, 186-196.
https://doi.org/10.1016/j.micpath.2019.04.015
Usjak D, Ivković B, Božić D, Bošković L, Milenković M. Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa. in Microbial Pathogenesis. 2019;131:186-196.
doi:10.1016/j.micpath.2019.04.015 .
Usjak, Dušan, Ivković, Branka, Božić, Dragana, Bošković, Lidija, Milenković, Marina, "Antimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosa" in Microbial Pathogenesis, 131 (2019):186-196,
https://doi.org/10.1016/j.micpath.2019.04.015 . .

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