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dc.creatorUsjak, Dušan
dc.creatorIvković, Branka
dc.creatorBožić, Dragana
dc.creatorBošković, Lidija
dc.creatorMilenković, Marina
dc.date.accessioned2019-09-02T12:11:21Z
dc.date.available2019-09-02T12:11:21Z
dc.date.issued2019
dc.identifier.issn0882-4010
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3351
dc.description.abstractAcinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. The aim of this study was to examine effectiveness of four newly-synthesized chalcones against the multiresistant clinical strains of A. baumannii and P. aeruginosa. Antibacterial activity of chalcones was investigated with broth-microdilution test and time-dependent killing assay. Synergistic effects of tested compounds with antibiotics (meropenem, amikacin and ciprofloxacin) were determined by checkerboard assay. The effects of chalcones on expression of virulence factors in P. aeruginosa (pyocyanin production, swimming and swarming motility) and A. baumannii (twitching and surface-associated motility), along with their biofilm production, were also examined. The obtained results indicate substantial antimicrobial activity of the tested chalcones (MICs = 100-175 mu g/mL) and several synergistic interactions with antibiotics, as well as notable reduction in expression of all investigated virulence factors. These promising results may constitute a good basis for further research.en
dc.publisherAcademic Press Ltd- Elsevier Science Ltd, London
dc.rightsrestrictedAccess
dc.sourceMicrobial Pathogenesis
dc.subjectChalconesen
dc.subjectAcinetobacter baumanniien
dc.subjectPseudomonas aeruginosaen
dc.subjectBiofilmen
dc.subjectMotilityen
dc.titleAntimicrobial activity of novel chalcones and modulation of virulence factors in hospital strains of Acinetobacter baumannii and Pseudomonas aeruginosaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиленковић, Марина; Ивковић, Бранка; Усјак, Душан; Божић, Драгана; Бошковић, Лидија;
dc.citation.volume131
dc.citation.spage186
dc.citation.epage196
dc.citation.other131: 186-196
dc.citation.rankM22
dc.identifier.wos000471208000026
dc.identifier.doi10.1016/j.micpath.2019.04.015
dc.identifier.pmid30980878
dc.identifier.scopus2-s2.0-85064077948
dc.identifier.rcubconv_4397
dc.type.versionpublishedVersion


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