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Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women

Само за регистроване кориснике
2019
Аутори
Tulić, Lidija
Vidaković, Snežana
Tulić, Ivan
Ćurčić, Marijana
Bulat, Zorica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документу
Апстракт
The aim of this study was to investigate the association of trace element and toxic metal concentrations in blood and the outcome of in vitro fertilization (IVF). The study included 104 consecutive patients that underwent assisted reproductive technology (ART) procedures. The following parameters were determined: cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb); and copper (Cu), zinc (Zn), selenium (Se), and magnesium (Mg). Serum samples were obtained before commencing stimulation. Patients with smoking habit had significantly higher Pb concentrations (P=0.022), as well as higher concentrations of As and Hg but not significantly. All subjects were divided into groups of pregnant and nonpregnant patients. Pregnant patients had lower mean values of Mg (P=0.009), As (P lt 0.05), and Pb (P=0.034), compared to nonpregnant, and a significant correlation between pregnancy outcome and concentrations of Mg, Cd, and Pb was found. Women who had had delivered had lower Mg (P=0.009) and Cd (...P=0.014) concentrations. There was a significant correlation of the negative outcome of IVF procedure with higher concentrations of Pb (P=0.046) and Cd (P=0.012). In conclusion, our results suggest that there is a difference in Mg, Pb, and Cd concentrations between pregnant and nonpregnant women. There was no association between toxic metals and number and quality of oocytes and embryos, while there was with fertilization rate. Concerning trace elements, we did not find the correlation of trace elements with oocyte number and quality, nor with a number of fertilized oocytes, except for Cu. Patients who were pregnant had lower concentrations of Mg.

Кључне речи:
In vitro fertilization / Pregnancy / Toxic metals / Trace elements
Извор:
Biological Trace Element Research, 2019, 188, 2, 284-294
Издавач:
  • Humana Press Inc, Totowa
Финансирање / пројекти:
  • Унапређење и развој хигијенских и технолошких поступака у производњи намирница животињског порекла у циљу добијања квалитетних и безбедних производа конкурентних на светском тржишту (RS-46009)

DOI: 10.1007/s12011-018-1421-z

ISSN: 0163-4984

PubMed: 29951726

WoS: 000461991600006

Scopus: 2-s2.0-85049115823
[ Google Scholar ]
15
6
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3359
Колекције
  • Radovi istraživača / Researchers’ publications
Институција/група
Pharmacy
TY  - JOUR
AU  - Tulić, Lidija
AU  - Vidaković, Snežana
AU  - Tulić, Ivan
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3359
AB  - The aim of this study was to investigate the association of trace element and toxic metal concentrations in blood and the outcome of in vitro fertilization (IVF). The study included 104 consecutive patients that underwent assisted reproductive technology (ART) procedures. The following parameters were determined: cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb); and copper (Cu), zinc (Zn), selenium (Se), and magnesium (Mg). Serum samples were obtained before commencing stimulation. Patients with smoking habit had significantly higher Pb concentrations (P=0.022), as well as higher concentrations of As and Hg but not significantly. All subjects were divided into groups of pregnant and nonpregnant patients. Pregnant patients had lower mean values of Mg (P=0.009), As (P lt 0.05), and Pb (P=0.034), compared to nonpregnant, and a significant correlation between pregnancy outcome and concentrations of Mg, Cd, and Pb was found. Women who had had delivered had lower Mg (P=0.009) and Cd (P=0.014) concentrations. There was a significant correlation of the negative outcome of IVF procedure with higher concentrations of Pb (P=0.046) and Cd (P=0.012). In conclusion, our results suggest that there is a difference in Mg, Pb, and Cd concentrations between pregnant and nonpregnant women. There was no association between toxic metals and number and quality of oocytes and embryos, while there was with fertilization rate. Concerning trace elements, we did not find the correlation of trace elements with oocyte number and quality, nor with a number of fertilized oocytes, except for Cu. Patients who were pregnant had lower concentrations of Mg.
PB  - Humana Press Inc, Totowa
T2  - Biological Trace Element Research
T1  - Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women
VL  - 188
IS  - 2
SP  - 284
EP  - 294
DO  - 10.1007/s12011-018-1421-z
ER  - 
@article{
author = "Tulić, Lidija and Vidaković, Snežana and Tulić, Ivan and Ćurčić, Marijana and Bulat, Zorica",
year = "2019",
abstract = "The aim of this study was to investigate the association of trace element and toxic metal concentrations in blood and the outcome of in vitro fertilization (IVF). The study included 104 consecutive patients that underwent assisted reproductive technology (ART) procedures. The following parameters were determined: cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb); and copper (Cu), zinc (Zn), selenium (Se), and magnesium (Mg). Serum samples were obtained before commencing stimulation. Patients with smoking habit had significantly higher Pb concentrations (P=0.022), as well as higher concentrations of As and Hg but not significantly. All subjects were divided into groups of pregnant and nonpregnant patients. Pregnant patients had lower mean values of Mg (P=0.009), As (P lt 0.05), and Pb (P=0.034), compared to nonpregnant, and a significant correlation between pregnancy outcome and concentrations of Mg, Cd, and Pb was found. Women who had had delivered had lower Mg (P=0.009) and Cd (P=0.014) concentrations. There was a significant correlation of the negative outcome of IVF procedure with higher concentrations of Pb (P=0.046) and Cd (P=0.012). In conclusion, our results suggest that there is a difference in Mg, Pb, and Cd concentrations between pregnant and nonpregnant women. There was no association between toxic metals and number and quality of oocytes and embryos, while there was with fertilization rate. Concerning trace elements, we did not find the correlation of trace elements with oocyte number and quality, nor with a number of fertilized oocytes, except for Cu. Patients who were pregnant had lower concentrations of Mg.",
publisher = "Humana Press Inc, Totowa",
journal = "Biological Trace Element Research",
title = "Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women",
volume = "188",
number = "2",
pages = "284-294",
doi = "10.1007/s12011-018-1421-z"
}
Tulić, L., Vidaković, S., Tulić, I., Ćurčić, M.,& Bulat, Z.. (2019). Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women. in Biological Trace Element Research
Humana Press Inc, Totowa., 188(2), 284-294.
https://doi.org/10.1007/s12011-018-1421-z
Tulić L, Vidaković S, Tulić I, Ćurčić M, Bulat Z. Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women. in Biological Trace Element Research. 2019;188(2):284-294.
doi:10.1007/s12011-018-1421-z .
Tulić, Lidija, Vidaković, Snežana, Tulić, Ivan, Ćurčić, Marijana, Bulat, Zorica, "Toxic Metal and Trace Element Concentrations in Blood and Outcome of In Vitro Fertilization in Women" in Biological Trace Element Research, 188, no. 2 (2019):284-294,
https://doi.org/10.1007/s12011-018-1421-z . .

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