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dc.creatorLeposavić, Gordana
dc.creatorPejčić-Karapetrović, Branka
dc.creatorKosec, Duško
dc.date.accessioned2019-09-02T10:54:26Z
dc.date.available2019-09-02T10:54:26Z
dc.date.issued2002
dc.identifier.issn0047-6374
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/335
dc.description.abstractIn adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping of thymus size and intrathymic T cell Maturation, In 4-month-old control rats the thymus size and cellularity returned to the corresponding levels in 1-month-old rats, These levels were sustained during the following 6 months. In spite of that, the distribution of the main thymocyte subsets in these rats as Subjected to significant changes, probably due to an age-associated diminishing thymus ability to provide efficient T cell differentiation. The results added further v.,eight to a potential feedback regulatory role of CD4+8- cells in thymopoiesis. Furthermore. they revealed that the orchidectomy-induced (i) enlargement of the thymus size and enrichment of the thymic lymphoid cell content are of a limited duration and (ii) alterations in the relative proportion of thymocytes become quantitatively more pronounced with duration of the gonadal deprivation. Thus, the study also indicates that the age-associated changes in gonadal hormones may be, at least partly. responsible For the age-related reshaping a of the T cell maturation sequence, and hence for remodeling T cell dependent immune functions.en
dc.publisherElsevier Sci Ireland Ltd, Clare
dc.rightsrestrictedAccess
dc.sourceMechanisms of Ageing and Development
dc.titleAlterations in thymopoiesis in intact and peripubertally orchidectomized adult rats of different ageen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЛепосавић, Гордана; Пејчић-Карапетровић, Бранка; Косец, Душко;
dc.citation.volume123
dc.citation.issue4
dc.citation.spage401
dc.citation.epage411
dc.citation.other123(4): 401-411
dc.citation.rankM21
dc.identifier.wos000177125000013
dc.identifier.doi10.1016/S0047-6374(01)00399-2
dc.identifier.pmid11744050
dc.identifier.scopus2-s2.0-0036138232
dc.identifier.rcubconv_1097
dc.type.versionpublishedVersion


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