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Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)

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2019
Authors
Savić, Ivan
Nikolić, Ivana Lj.
Savić-Gajić, Ivana
Kundaković, Tatjana
Article (Published version)
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Abstract
The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
Keywords:
Chickpea / total polyphenol / total flavonoid / antioxidant activity / central composite design
Source:
Solid State Ionics, 2019, 54, 5, 837-846
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.1080/01496395.2018.1520720

ISSN: 0149-6395

WoS: 000464574300018

Scopus: 2-s2.0-85053510649
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3362
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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