The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
Keywords:
Chickpea / total polyphenol / total flavonoid / antioxidant activity / central composite design
TY - JOUR
AU - Savić, Ivan
AU - Nikolić, Ivana Lj.
AU - Savić-Gajić, Ivana
AU - Kundaković, Tatjana
PY - 2019
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3362
AB - The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
PB - Taylor & Francis Inc, Philadelphia
T2 - Solid State Ionics
T1 - Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)
VL - 54
IS - 5
SP - 837
EP - 846
DO - 10.1080/01496395.2018.1520720
ER -
@article{
author = "Savić, Ivan and Nikolić, Ivana Lj. and Savić-Gajić, Ivana and Kundaković, Tatjana",
year = "2019",
abstract = "The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Solid State Ionics",
title = "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)",
volume = "54",
number = "5",
pages = "837-846",
doi = "10.1080/01496395.2018.1520720"
}
Savić, I., Nikolić, I. Lj., Savić-Gajić, I.,& Kundaković, T.. (2019). Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics
Taylor & Francis Inc, Philadelphia., 54(5), 837-846.
https://doi.org/10.1080/01496395.2018.1520720
Savić I, Nikolić IL, Savić-Gajić I, Kundaković T. Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics. 2019;54(5):837-846.
doi:10.1080/01496395.2018.1520720 .
Savić, Ivan, Nikolić, Ivana Lj., Savić-Gajić, Ivana, Kundaković, Tatjana, "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)" in Solid State Ionics, 54, no. 5 (2019):837-846,
https://doi.org/10.1080/01496395.2018.1520720 . .
