FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)

Authorized Users Only
2019
Authors
Savić, Ivan
Nikolić, Ivana Lj.
Savić-Gajić, Ivana
Kundaković, Tatjana
Article (Published version)
Metadata
Show full item record
Abstract
The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
Keywords:
Chickpea / total polyphenol / total flavonoid / antioxidant activity / central composite design
Source:
Solid State Ionics, 2019, 54, 5, 837-846
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)

DOI: 10.1080/01496395.2018.1520720

ISSN: 0149-6395

WoS: 000464574300018

Scopus: 2-s2.0-85053510649
[ Google Scholar ]
4
2
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3362
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Savić, Ivan
AU  - Nikolić, Ivana Lj.
AU  - Savić-Gajić, Ivana
AU  - Kundaković, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3362
AB  - The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).
PB  - Taylor & Francis Inc, Philadelphia
T2  - Solid State Ionics
T1  - Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)
VL  - 54
IS  - 5
SP  - 837
EP  - 846
DO  - 10.1080/01496395.2018.1520720
ER  - 
@article{
author = "Savić, Ivan and Nikolić, Ivana Lj. and Savić-Gajić, Ivana and Kundaković, Tatjana",
year = "2019",
abstract = "The aim of study was to model and optimize the extraction of polyphenols and flavonoids with expressed antioxidant activity from chickpea seeds using a central composite design. The optimal extraction conditions were the extraction time of 145.5 min, ethanol concentration of 83.7% and liquid-to-solid ratio of 24.9 (expressed as cm(3) per g). The content of total polyphenol and flavonoid was 2.75 g gallic acid equivalent per kilogram of the dried extract and 0.147 g rutin equivalent per kilogram of the dried extract, respectively. Using 2,2-diphenyl-1-picrylhydrazyl assay, it was found that the optimal extract had the IC50 of 1.55 mg cm(-3).",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Solid State Ionics",
title = "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)",
volume = "54",
number = "5",
pages = "837-846",
doi = "10.1080/01496395.2018.1520720"
}
Savić, I., Nikolić, I. Lj., Savić-Gajić, I.,& Kundaković, T.. (2019). Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics
Taylor & Francis Inc, Philadelphia., 54(5), 837-846.
https://doi.org/10.1080/01496395.2018.1520720
Savić I, Nikolić IL, Savić-Gajić I, Kundaković T. Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L). in Solid State Ionics. 2019;54(5):837-846.
doi:10.1080/01496395.2018.1520720 .
Savić, Ivan, Nikolić, Ivana Lj., Savić-Gajić, Ivana, Kundaković, Tatjana, "Modeling and optimization of bioactive compounds from chickpea seeds (Cicer arietinum L)" in Solid State Ionics, 54, no. 5 (2019):837-846,
https://doi.org/10.1080/01496395.2018.1520720 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB