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dc.creatorArdalić, Daniela
dc.creatorStefanović, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorNinić, Ana
dc.creatorSpasić, Slavica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.creatorMiković, Željko
dc.date.accessioned2019-09-02T12:11:55Z
dc.date.available2019-09-02T12:11:55Z
dc.date.issued2019
dc.identifier.issn2567-9430
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3370
dc.description.abstractBackground: Specific metabolic changes during physiological pregnancy are characterized by hyperlipidemia and increased oxidative stress. However, these specific changes raise the question of their pro-atherogenic potential during pregnancy and their influence on the risk of developing cardiovascular disease (CVD) in women later in life, as well as complications during pregnancy. The aim of this study was to investigate the changes in lipid indexes and parameters of lipid peroxidation in non-complicated pregnancy in order to estimate their course of change and potential relationship during non-complicated pregnancy. Methods: The study included 43 healthy pregnant women and 38 non-pregnant healthy women, in appropriate ages, as the control group. Lipid parameters and oxidative stress parameters were monitored in a longitudinal study in the first, second and third trimesters, and before delivery during non-complicated pregnancy. Results: Results have shown that lipid indexes rise during pregnancy. The values were significantly increased when compared to the first trimester in all lipid indices and in comparison with the control group. Thyobarbituric acid reactive substances (TBARS) and lipid hydroperoxides (LOOH) were not changed significantly during physiological pregnancy, but LOOH showed a significantly higher value in the first trimester compared with the control group. Prooxidative-antioxidative balance (PAB) significantly increases as pregnancy progresses. Conclusions: We observed the changes in lipids, lipid indexes and parameters that indicate oxidative modification of lipids in physiological pregnancy that may lead to an atherogenic, prooxidant state.en
dc.publisherWalter de Gruyter Gmbh, Berlin
dc.rightsrestrictedAccess
dc.sourceJournal of Laboratory Medicine
dc.subjecthyperlipidemiaen
dc.subjectlipid indexesen
dc.subjectlipid peroxidationen
dc.subjectpregnancyen
dc.titleLipid indexes and parameters of lipid peroxidation during physiological pregnancyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКотур-Стевуљевић, Јелена; Спасић, Славица; Миковић, Жељко; Јелић-Ивановић, Зорана; Стефановић, Aлександра; Aрдалић, Даниела; Спасојевић-Калимановска, Весна; Нинић, Aна;
dc.citation.volume43
dc.citation.issue2
dc.citation.spage93
dc.citation.epage99
dc.citation.other43(2): 93-99
dc.citation.rankM23
dc.identifier.wos000467144300006
dc.identifier.doi10.1515/labmed-2018-0026
dc.identifier.scopus2-s2.0-85063454139
dc.identifier.rcubconv_4369
dc.type.versionpublishedVersion


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