Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System
Authors
Rakić, TijanaJančić-Stojanović, Biljana

Jovanović, Marko
Malenović, Anđelija

Ivanović, Darko
Medenica, Mirjana
Article (Published version)
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This paper investigates the ability of seven chromatographic response functions to measure the quality of chromatograms obtained in hydrophilic interaction liquid chromatography (HILIC). First, the functions were tested on a set of simulated chromatograms and differences in their mathematical design were discussed. Second, the functions were evaluated on the experimentally obtained chromatograms in HILIC analysis of model mixture consisted of beta agonists and antagonists. The ranking of chromatograms obtained by different functions was significantly different, implying that the accuracy of the optimization procedure is strongly dependent on the function that was selected as an output. Investigation of potential drawbacks of each function was conducted and general recommendations concerning the use of chromatographic response functions in optimization strategies are proposed.
Keywords:
Beta agonists and antagonists / Chromatographic response function (CRF) / HILICSource:
Analytical Letters, 2013, 46, 8, 1198-1212Publisher:
- Taylor & Francis Inc, Philadelphia
Funding / projects:
- Modelling of different chromatographic systems with chemometrical approach in pharmaceutical analysis (RS-172052)
Note:
- This is peer-reviewed version of the following article: Rakić, T.; Stojanović, B. J.; Jovanović, M.; Malenović, A.; Ivanović, D.; Medenica, M. Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System. Anal. Lett. 2013, 46 (8), 1198–1212. https://doi.org/10.1080/00032719.2012.755689
DOI: 10.1080/00032719.2012.755689
ISSN: 0003-2719
WoS: 000318281700002
Scopus: 2-s2.0-84877274218
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Institution/Community
PharmacyTY - JOUR AU - Rakić, Tijana AU - Jančić-Stojanović, Biljana AU - Jovanović, Marko AU - Malenović, Anđelija AU - Ivanović, Darko AU - Medenica, Mirjana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3419 AB - This paper investigates the ability of seven chromatographic response functions to measure the quality of chromatograms obtained in hydrophilic interaction liquid chromatography (HILIC). First, the functions were tested on a set of simulated chromatograms and differences in their mathematical design were discussed. Second, the functions were evaluated on the experimentally obtained chromatograms in HILIC analysis of model mixture consisted of beta agonists and antagonists. The ranking of chromatograms obtained by different functions was significantly different, implying that the accuracy of the optimization procedure is strongly dependent on the function that was selected as an output. Investigation of potential drawbacks of each function was conducted and general recommendations concerning the use of chromatographic response functions in optimization strategies are proposed. PB - Taylor & Francis Inc, Philadelphia T2 - Analytical Letters T1 - Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System VL - 46 IS - 8 SP - 1198 EP - 1212 DO - 10.1080/00032719.2012.755689 ER -
@article{ author = "Rakić, Tijana and Jančić-Stojanović, Biljana and Jovanović, Marko and Malenović, Anđelija and Ivanović, Darko and Medenica, Mirjana", year = "2013", abstract = "This paper investigates the ability of seven chromatographic response functions to measure the quality of chromatograms obtained in hydrophilic interaction liquid chromatography (HILIC). First, the functions were tested on a set of simulated chromatograms and differences in their mathematical design were discussed. Second, the functions were evaluated on the experimentally obtained chromatograms in HILIC analysis of model mixture consisted of beta agonists and antagonists. The ranking of chromatograms obtained by different functions was significantly different, implying that the accuracy of the optimization procedure is strongly dependent on the function that was selected as an output. Investigation of potential drawbacks of each function was conducted and general recommendations concerning the use of chromatographic response functions in optimization strategies are proposed.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Analytical Letters", title = "Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System", volume = "46", number = "8", pages = "1198-1212", doi = "10.1080/00032719.2012.755689" }
Rakić, T., Jančić-Stojanović, B., Jovanović, M., Malenović, A., Ivanović, D.,& Medenica, M.. (2013). Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System. in Analytical Letters Taylor & Francis Inc, Philadelphia., 46(8), 1198-1212. https://doi.org/10.1080/00032719.2012.755689
Rakić T, Jančić-Stojanović B, Jovanović M, Malenović A, Ivanović D, Medenica M. Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System. in Analytical Letters. 2013;46(8):1198-1212. doi:10.1080/00032719.2012.755689 .
Rakić, Tijana, Jančić-Stojanović, Biljana, Jovanović, Marko, Malenović, Anđelija, Ivanović, Darko, Medenica, Mirjana, "Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System" in Analytical Letters, 46, no. 8 (2013):1198-1212, https://doi.org/10.1080/00032719.2012.755689 . .