Estimation of the hydrophobicity of antimycotic compounds by planar chromatography
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2002
Authors
Aleksić, MirjanaErić, Slavica
Agbaba, Danica

Odović, Jadranka

Milojković-Opsenica, Dušanka

Tesić, I
Article (Published version)

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Show full item recordAbstract
The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.
Source:
Journal of Planar Chromatography - Modern TLC, 2002, 15, 6, 414-417Publisher:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.15.2002.6.4
ISSN: 0933-4173