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Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract

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2018
Thermosensitive_Hydrogels_for_acc_2017.pdf (1.017Mb)
Authors
Ilić-Stojanović, Snežana
Nikolić, Vesna D.
Kundaković, Tatjana
Savić, Ivan
Savić-Gajić, Ivana
Jocić, Emilija
Nikolić, Ljubiša
Article (Published version)
Metadata
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Abstract
Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl ass...ay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]

Keywords:
Alchemilla vulgaris L / ellagic acid / hydrogels / N-isopropylacrylamide / thermosensitive release
Source:
International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, 67, 9, 553-563
Publisher:
  • Taylor & Francis As, Oslo
Funding / projects:
  • Plants and synthetic bioactive products of new generation (RS-34012)
Note:
  • This is peer-reviewed version of the following article: Ilić-Stojanović, S.; Nikolić, V.; Kundaković, T.; Savić, I.; Savić-Gajić, I.; Jocić, E.; Nikolić, L. Thermosensitive Hydrogels for Modified Release of Ellagic Acid Obtained from Alchemilla Vulgaris L. Extract. Int. J. Polym. Mater. Polym. Biomater. 2018, 67 (9), 553–563. https://doi.org/10.1080/00914037.2017.1354202

DOI: 10.1080/00914037.2017.1354202

ISSN: 0091-4037

WoS: 000429604500003

Scopus: 2-s2.0-85029429225
[ Google Scholar ]
9
9
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3421
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
AU  - Savić, Ivan
AU  - Savić-Gajić, Ivana
AU  - Jocić, Emilija
AU  - Nikolić, Ljubiša
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3421
AB  - Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]
PB  - Taylor & Francis As, Oslo
T2  - International Journal of Polymeric Materials and Polymeric Biomaterials
T1  - Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract
VL  - 67
IS  - 9
SP  - 553
EP  - 563
DO  - 10.1080/00914037.2017.1354202
ER  - 
@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Kundaković, Tatjana and Savić, Ivan and Savić-Gajić, Ivana and Jocić, Emilija and Nikolić, Ljubiša",
year = "2018",
abstract = "Stimulus-sensitive hydrogels are used as carriers for modified release of pharmaceuticals. The synthesis of thermosensitive hydrogels poly(N-isopropylacrylamide), p(NIPAM), and poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate), p(NIPAM-HPMet), is performed. The synthesized hydrogels are characterized using FTIR and scanning electron microscope methods and swelling properties, and applied for modified release of ellagic acid (EA). This work presents the selective extraction of EA, as a natural antioxidant, from the aerial parts of Alchemilla vulgaris L. EA and A. vulgaris extract are incorporated into p(NIPAM) and p(NIPAM-HPMet) hydrogels and characterized by FTIR method. The EA content in the extract by the UHPLC-DAD-HESI-MS/MS method is determined (0.64mgcm(-3)). The total flavonoids content in the A. vulgaris extract was determined by the spectrophotometric method. Antioxidant activity of the A. vulgaris extract and EA is examined using the 2,2-diphenyl-1-picrylhydrazyl assay. The p(NIPAM-HPMet) shows a better incorporation and release at 37 degrees C of EA standard and A. vulgaris extract (98.87 and 96.45% respectively), compared with p(NIPAM). [GRAPHICS]",
publisher = "Taylor & Francis As, Oslo",
journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",
title = "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract",
volume = "67",
number = "9",
pages = "553-563",
doi = "10.1080/00914037.2017.1354202"
}
Ilić-Stojanović, S., Nikolić, V. D., Kundaković, T., Savić, I., Savić-Gajić, I., Jocić, E.,& Nikolić, L.. (2018). Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials
Taylor & Francis As, Oslo., 67(9), 553-563.
https://doi.org/10.1080/00914037.2017.1354202
Ilić-Stojanović S, Nikolić VD, Kundaković T, Savić I, Savić-Gajić I, Jocić E, Nikolić L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. in International Journal of Polymeric Materials and Polymeric Biomaterials. 2018;67(9):553-563.
doi:10.1080/00914037.2017.1354202 .
Ilić-Stojanović, Snežana, Nikolić, Vesna D., Kundaković, Tatjana, Savić, Ivan, Savić-Gajić, Ivana, Jocić, Emilija, Nikolić, Ljubiša, "Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract" in International Journal of Polymeric Materials and Polymeric Biomaterials, 67, no. 9 (2018):553-563,
https://doi.org/10.1080/00914037.2017.1354202 . .

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