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Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid
dc.creator | Antonijević-Nikolić, Mirjana | |
dc.creator | Antić-Stanković, Jelena | |
dc.creator | Tanasković, Slađana | |
dc.date.accessioned | 2019-09-12T16:22:04Z | |
dc.date.available | 2019-04-02 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3083 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3426 | |
dc.description.abstract | AbstrcatNew cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N,N,N-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co-4(pma)(tpmc)(2)](ClO4)(4)6H(2)O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO- from pma participates in coordination with one Co(II). In the case of [Cu-2(pma)tpmc].8H(2)O (2), one OCO- from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt's lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 +/- 2.39 to 152.40 +/- 2.28M, and from 140.88 +/- 3.51 to 192.05 +/- 2.09M, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25mM. Complex 2 did not express activity against tested microbial strains. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS// | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of Coordination Chemistry | |
dc.subject | Co(II) and Cu(II) Complexes | en |
dc.subject | tpmc | en |
dc.subject | pyromellitate ligand | en |
dc.subject | antimicrobial activity | en |
dc.subject | cytotoxic activity | en |
dc.title | Synthesis, characterization, and in vitro antiproliferative and antibacterial studies of tetraazamacrocyclic complexes of Co(II) and Cu(II) with pyromellitic acid | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Aнтонијевић-Николић, Мирјана; Танасковић, Слађана; Aнтић-Станковић, Јелена; | |
dc.citation.volume | 71 | |
dc.citation.issue | 10 | |
dc.citation.spage | 1542 | |
dc.citation.epage | 1559 | |
dc.citation.other | 71(10): 1542-1559 | |
dc.citation.rank | M22 | |
dc.description.other | This is peer-reviewed version of the following article: Nikolić, M. A.; Stanković, J. A.; Tanasković, S. B. Synthesis, Characterization, and in Vitro Antiproliferative and Antibacterial Studies of Tetraazamacrocyclic Complexes of Co(II) and Cu(II) with Pyromellitic Acid. J. Coord. Chem. 2018, 71 (10), 1542–1559. [https://doi.org/10.1080/00958972.2018.1459581] | |
dc.identifier.wos | 000444589600006 | |
dc.identifier.doi | 10.1080/00958972.2018.1459581 | |
dc.identifier.scopus | 2-s2.0-85045765182 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/7177/Synthesis_characterization_and_acc_2018.pdf | |
dc.type.version | acceptedVersion | |
dc.type.version | publishedVersion |