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Implications of oxidative stress in occupational exposure to lead on a cellular level

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2015
Implications_of_oxidative_acc_2015.pdf (1.113Mb)
Authors
Čabarkapa, Andrea
Borozan, Sunčica
Živković, Lada
Milanović-Čabarkapa, Mirjana
Stojanović, Srđan
Bajić, Vladan
Spremo-Potparević, Biljana
Article (Accepted Version)
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Abstract
The aim of this study was to determine oxidative alterations leading to cellular dysfunctions in Pb-exposed subjects by evaluating damage to all major classes of biomolecules in the cell, lipid peroxidation, protein and DNA damage and determine relationships between parameters of Pb toxicity and specific biomarkers of oxidative damage.Analysis was conducted of smelter workers with high blood Pb and urine aminolevulinic acid levels and slightly elevated values of coproporphyrin and erythrocyte protoporphyrin IX. Significant decreases of thiol groups and increases in carbonyl groups as protein degradation end products, and of nitrite were detected. Elevated rates of lipid peroxidation and rises in the activities of the antioxidant enzymes Cu-Zn superoxide dismutase and catalase were also observed. Both enzymes showed positive correlations with the blood lead levels and urine coproporphyrin, while thiol groups correlated negatively with the same indices. The genotoxic potential of lead wa...s manifested through an increased number of DNA-damaged cells. Increased activities of serum lactate dehydrogenase isoenzymes indicated cellular damage in the lungs, kidneys, and liver. These lead-induced impairments should be taken into consideration in the assessment of Pb-related health hazards.

Keywords:
lead (Pb) / oxidative stress / DNA damage / protein oxidative modification / cell membrane damage
Source:
Toxicology, 2015, 97, 6, 799-813
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)
Note:
  • This is peer-reviewed version of the following article: Čabarkapa, A.; Borozan, S.; Živković, L.; Milanović-Čabarkapa, M.; Stojanović, S.; Bajić, V.; Spremo-Potparević, B. Implications of Oxidative Stress in Occupational Exposure to Lead on a Cellular Level. Toxicol. Environ. Chem. 2015, 97 (6), 799–813. https://doi.org/10.1080/02772248.2015.1060973

DOI: 10.1080/02772248.2015.1060973

ISSN: 0277-2248

WoS: 000359795300009

Scopus: 2-s2.0-84938743717
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2440
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3428
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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