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Optimization of TLC method for separation and determination of ziprasidone and its impurities

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Optimization_of_TLC_acc_2016.pdf (681.1Kb)
Authors
Obradović, Darija
Filipić, Slavica
Nikolić, Katarina
Carapić, Marija
Agbaba, Danica
Article (Accepted Version)
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Abstract
A thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60 F-254 and using toluene-methanol-glacial acetic acid, 7.5:0.5:0.5 (v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile-phase vapors for 15 min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 250 and 320 nm. Regression coefficient (r >= 0.992), recovery (94.94-106.70%), limit of quantification of impurities (25 ng band(-1) equivalent to the 0.14% impurity level), and robustness were validated and found satisfactory. The developed method is convenient for quantitative analysis and the purity screening of ziprasidone in pharmaceutical formulations.
Source:
Journal of Liquid Chromatography & Related Technologies, 2016, 39, 5-6, 271-276
Publisher:
  • Taylor & Francis Inc, Philadelphia
Funding / projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)
Note:
  • This is peer-reviewed version of the following article: Obradović, D.; Filipić, S.; Nikolić, K.; Čarapić, M.; Agbaba, D. Optimization of TLC Method for Separation and Determination of Ziprasidone and Its Impurities. J. Liq. Chromatogr. Relat. Technol. 2016, 39 (5–6), 271–276. https://doi.org/10.1080/10826076.2016.1163183

DOI: 10.1080/10826076.2016.1163183

ISSN: 1082-6076

WoS: 000378000800006

Scopus: 2-s2.0-84969180492
[ Google Scholar ]
6
5
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3433
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Obradović, Darija
AU  - Filipić, Slavica
AU  - Nikolić, Katarina
AU  - Carapić, Marija
AU  - Agbaba, Danica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3433
AB  - A thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60 F-254 and using toluene-methanol-glacial acetic acid, 7.5:0.5:0.5 (v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile-phase vapors for 15 min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 250 and 320 nm. Regression coefficient (r >= 0.992), recovery (94.94-106.70%), limit of quantification of impurities (25 ng band(-1) equivalent to the 0.14% impurity level), and robustness were validated and found satisfactory. The developed method is convenient for quantitative analysis and the purity screening of ziprasidone in pharmaceutical formulations.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Optimization of TLC method for separation and determination of ziprasidone and its impurities
VL  - 39
IS  - 5-6
SP  - 271
EP  - 276
DO  - 10.1080/10826076.2016.1163183
ER  - 
@article{
author = "Obradović, Darija and Filipić, Slavica and Nikolić, Katarina and Carapić, Marija and Agbaba, Danica",
year = "2016",
abstract = "A thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60 F-254 and using toluene-methanol-glacial acetic acid, 7.5:0.5:0.5 (v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile-phase vapors for 15 min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 250 and 320 nm. Regression coefficient (r >= 0.992), recovery (94.94-106.70%), limit of quantification of impurities (25 ng band(-1) equivalent to the 0.14% impurity level), and robustness were validated and found satisfactory. The developed method is convenient for quantitative analysis and the purity screening of ziprasidone in pharmaceutical formulations.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Optimization of TLC method for separation and determination of ziprasidone and its impurities",
volume = "39",
number = "5-6",
pages = "271-276",
doi = "10.1080/10826076.2016.1163183"
}
Obradović, D., Filipić, S., Nikolić, K., Carapić, M.,& Agbaba, D.. (2016). Optimization of TLC method for separation and determination of ziprasidone and its impurities. in Journal of Liquid Chromatography & Related Technologies
Taylor & Francis Inc, Philadelphia., 39(5-6), 271-276.
https://doi.org/10.1080/10826076.2016.1163183
Obradović D, Filipić S, Nikolić K, Carapić M, Agbaba D. Optimization of TLC method for separation and determination of ziprasidone and its impurities. in Journal of Liquid Chromatography & Related Technologies. 2016;39(5-6):271-276.
doi:10.1080/10826076.2016.1163183 .
Obradović, Darija, Filipić, Slavica, Nikolić, Katarina, Carapić, Marija, Agbaba, Danica, "Optimization of TLC method for separation and determination of ziprasidone and its impurities" in Journal of Liquid Chromatography & Related Technologies, 39, no. 5-6 (2016):271-276,
https://doi.org/10.1080/10826076.2016.1163183 . .

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