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dc.creatorObradović, Darija
dc.creatorFilipić, Slavica
dc.creatorNikolić, Katarina
dc.creatorCarapić, Marija
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-14T21:28:26Z
dc.date.available2017-03-10
dc.date.issued2016
dc.identifier.issn1082-6076
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3433
dc.description.abstractA thin-layer chromatographic method for simultaneous determination of ziprasidone and its main impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60 F-254 and using toluene-methanol-glacial acetic acid, 7.5:0.5:0.5 (v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile-phase vapors for 15 min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 250 and 320 nm. Regression coefficient (r >= 0.992), recovery (94.94-106.70%), limit of quantification of impurities (25 ng band(-1) equivalent to the 0.14% impurity level), and robustness were validated and found satisfactory. The developed method is convenient for quantitative analysis and the purity screening of ziprasidone in pharmaceutical formulations.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsembargoedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.titleOptimization of TLC method for separation and determination of ziprasidone and its impuritiesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractAгбаба, Даница; Филипић, Славица; Обрадовић, Дарија; Николић, Катарина; Царапић, Марија;
dc.citation.volume39
dc.citation.issue5-6
dc.citation.spage271
dc.citation.epage276
dc.citation.other39(5-6): 271-276
dc.citation.rankM23
dc.description.otherThis is peer-reviewed version of the following article: Obradović, D.; Filipić, S.; Nikolić, K.; Čarapić, M.; Agbaba, D. Optimization of TLC Method for Separation and Determination of Ziprasidone and Its Impurities. J. Liq. Chromatogr. Relat. Technol. 2016, 39 (5–6), 271–276. [https://doi.org/10.1080/10826076.2016.1163183]
dc.identifier.wos000378000800006
dc.identifier.doi10.1080/10826076.2016.1163183
dc.identifier.scopus2-s2.0-84969180492
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7169/Optimization_of_TLC_acc_2016.pdf
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dc.type.versionpublishedVersion


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