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Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography

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2015
Determination_of_Moxonidine_acc_2015.pdf (467.5Kb)
Authors
Filipić, Slavica
Shenger, Musbah Salem Mohamed
Nikolić, Katarina
Agbaba, Danica
Article (Accepted Version)
Metadata
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Abstract
A thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.
Keywords:
pharmaceuticals / moxonidine / method validation / quantitation / impurities / TLC
Source:
Journal of Liquid Chromatography & Related Technologies, 2015, 38, 11, 1121-1125
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Synthesis, Quantitative Structure and Activity Relationship, Physico-Chemical Characterisation and Analysis of Pharmacologically Active Substances (RS-172033)
Note:
  • This is peer-reviewed version of the following article: Filipic, S.; Shenger, M. S. M.; Nikolic, K.; Agbaba, D. Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (11), 1121–1125. https://doi.org/10.1080/10826076.2015.1028291

DOI: 10.1080/10826076.2015.1028291

ISSN: 1082-6076

WoS: 000354045900006

Scopus: 2-s2.0-84929231814
[ Google Scholar ]
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2
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2391
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3439
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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