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dc.creatorFilipić, Slavica
dc.creatorShenger, Musbah Salem Mohamed
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-14T21:39:49Z
dc.date.available2016-03-18
dc.date.issued2015
dc.identifier.issn1082-6076
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2391
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3439
dc.description.abstractA thin-layer chromatographic method for simultaneous determination of moxonidine and its four impurities was developed and validated. Separation of the examined compounds was performed on chromatographic plates precoated with silica gel 60F(254) and using methanol-toluene-dichloroethane-ammonia 2:3:3:0.1 (v/v/v/v) as mobile phase. Ascending development mode was performed in the twin-trough chromatographic chamber, which was presaturated with mobile phase vapors for 15min. The developed chromatographic plates were dried in air and densitometrically scanned at the wavelengths of 260 and 280nm. Regression coefficients (r >= 0.998), recovery (90.10-107.63%), limit of quantification of impurities (20ng band(-1) equivalent to the 0.12% impurity level), and robustness were validated and found satisfactory. The developed method is well suited for quantitative analysis and purity control of moxonidine in its dosage forms.en
dc.publisherTaylor & Francis Inc, Philadelphia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsembargoedAccess
dc.sourceJournal of Liquid Chromatography & Related Technologies
dc.subjectpharmaceuticalsen
dc.subjectmoxonidineen
dc.subjectmethod validationen
dc.subjectquantitationen
dc.subjectimpuritiesen
dc.subjectTLCen
dc.titleDetermination of Moxonidine and Its Impurities by Thin-Layer Chromatographyen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractНиколић, Катарина; Филипић, Славица; Aгбаба, Даница; Схенгер, Мусбах Салем Мохамед;
dc.citation.volume38
dc.citation.issue11
dc.citation.spage1121
dc.citation.epage1125
dc.citation.other38(11): 1121-1125
dc.citation.rankM23
dc.description.otherThis is peer-reviewed version of the following article: Filipic, S.; Shenger, M. S. M.; Nikolic, K.; Agbaba, D. Determination of Moxonidine and Its Impurities by Thin-Layer Chromatography. J. Liq. Chromatogr. Relat. Technol. 2015, 38 (11), 1121–1125. [https://doi.org/10.1080/10826076.2015.1028291]
dc.identifier.wos000354045900006
dc.identifier.doi10.1080/10826076.2015.1028291
dc.identifier.scopus2-s2.0-84929231814
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7147/Determination_of_Moxonidine_acc_2015.pdf
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dc.type.versionpublishedVersion


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