Abstract
Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythr...ocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.
TY - JOUR
AU - Karaulov, A.V.
AU - Renieri, E.A.
AU - Smolyagin, A.I.
AU - Mikhaylova, I.V.
AU - Stadnikov, A.A.
AU - Begun, D.N.
AU - Tsarouhas, K.
AU - Buha-Đorđević, Aleksandra
AU - Hartung, T.
AU - Tsatsakis, A.
PY - 2019
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3450
AB - Abstract
Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.
PB - Elsevier
T2 - Food and Chemical Toxicology
T1 - Long-term effects of chromium on morphological and immunological parameters of Wistar rats
VL - 133
SP - 1
EP - 11
DO - 10.1016/j.fct.2019.110748
ER -
@article{
author = "Karaulov, A.V. and Renieri, E.A. and Smolyagin, A.I. and Mikhaylova, I.V. and Stadnikov, A.A. and Begun, D.N. and Tsarouhas, K. and Buha-Đorđević, Aleksandra and Hartung, T. and Tsatsakis, A.",
year = "2019",
abstract = "Abstract
Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Long-term effects of chromium on morphological and immunological parameters of Wistar rats",
volume = "133",
pages = "1-11",
doi = "10.1016/j.fct.2019.110748"
}
Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, A., Hartung, T.,& Tsatsakis, A.. (2019). Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology
Elsevier., 133, 1-11.
https://doi.org/10.1016/j.fct.2019.110748
Karaulov A, Renieri E, Smolyagin A, Mikhaylova I, Stadnikov A, Begun D, Tsarouhas K, Buha-Đorđević A, Hartung T, Tsatsakis A. Long-term effects of chromium on morphological and immunological parameters of Wistar rats. in Food and Chemical Toxicology. 2019;133:1-11.
doi:10.1016/j.fct.2019.110748 .
Karaulov, A.V., Renieri, E.A., Smolyagin, A.I., Mikhaylova, I.V., Stadnikov, A.A., Begun, D.N., Tsarouhas, K., Buha-Đorđević, Aleksandra, Hartung, T., Tsatsakis, A., "Long-term effects of chromium on morphological and immunological parameters of Wistar rats" in Food and Chemical Toxicology, 133 (2019):1-11,
https://doi.org/10.1016/j.fct.2019.110748 . .
