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dc.creatorKaraulov, A.V.
dc.creatorRenieri, E.A.
dc.creatorSmolyagin, A.I.
dc.creatorMikhaylova, I.V.
dc.creatorStadnikov, A.A.
dc.creatorBegun, D.N.
dc.creatorTsarouhas, K.
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorHartung, T.
dc.creatorTsatsakis, A.
dc.date.accessioned2019-10-15T10:49:13Z
dc.date.available2019-10-15T10:49:13Z
dc.date.issued2019
dc.identifier.issn0278-6915
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3450
dc.description.abstractAbstract Hexavalent chromium raises high concern because of its wide industrial applications and reported toxicity. Long-term (135 days) oral exposure of Wistar rats to chromium in the form of K2Cr2O7 (exposed group~20 mg/kg/day) led to a decrease in thymus mass and thymocytes' number and caused structural and functional changes in the lymph nodes and spleen, namely lymphoreticular hyperplasia and plasmocytic macrophage transformation. Programmed cell death was increased in both thymocytes and splenocytes and decreased in lymphocytes in the T-zones of spleen and lymph nodes. Moreover, Cr (VI) administration decreased myeloid cells' and neutrophils' number, while it increased lymphoid and erythroid cells' number in bone marrow. Cr (VI) immune system effects seem to be related to oxidative stress induction, as depicted by the increased levels of diene conjugates and malondialdehyde in the spleen and liver and by the decreased activity of catalase and superoxide dismutase in rats’ erythrocytes. In addition, exposure to Cr (VI) decreased copper, nickel and iron concentrations in blood and liver, while Cr levels in blood, spleen and liver were increased, as expected. The observed changes in the series of immunological parameters studied contribute to the development of new approaches for the prevention of low level Cr exposure toxicity.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationSpecial Research Account of University of Crete (ELKE No 4920), the University of Crete spin-off ToxPlus S.A.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceFood and Chemical Toxicology
dc.subjectChromiumsr
dc.subjectImmunotoxicitysr
dc.subjectRatssr
dc.subjectOxidative stresssr
dc.subjectMicroelementssr
dc.titleLong-term effects of chromium on morphological and immunological parameters of Wistar ratssr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractБуха-Ђорђевић, Aлександра; Караулов, A.В.; Рениери, Е.A.; Смолyагин, A.И.; Микхаyлова, И.В.; Стадников, A.A.; Бегун, Д.Н.; Тсароухас, К.; Хартунг, Т.; Тсатсакис, A.;
dc.citation.volume133
dc.citation.spage1
dc.citation.epage11
dc.citation.rankaM21
dc.description.otherPeer-reviewr.manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3451]
dc.identifier.wos000491684000006
dc.identifier.doi10.1016/j.fct.2019.110748
dc.identifier.scopus2-s2.0-85072746776
dc.type.versionpublishedVersionsr


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