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dc.creatorŽivković, Lada
dc.creatorBajić, Vladan
dc.creatorBruić, Marija
dc.creatorBorozan, Sunčica
dc.creatorPopić, Kristina
dc.creatorTopalović, Dijana
dc.creatorSantibanez, Juan
dc.creatorSpremo-Potparević, Biljana
dc.date.accessioned2019-10-29T09:58:23Z
dc.date.available2019-10-29T09:58:23Z
dc.date.issued2019
dc.identifier.issn1383-5718
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3456
dc.description.abstractImmune Assist (IA) is produced from extract of six species of medical mushrooms: Agaricus blazei - Cordyceps sinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The genoprotective potential of IA was evaluated for the first time. Significant antigenotoxic effects were detected in human peripheral blood cells against H2O2 induced DNA damage, in the pretreatment and in the posttreatment. The most efficient concentration of IA in pretreatment was 500 μg/mL, while in posttreatment it was the concentration of 250 μg/mL. Kinetics of attenuation of H2O2 induced DNA damage in posttreatment with the optimal concentration of IA showed significant decrease in the number of damaged cells at all time periods (15–60 min), reaching the greatest reduction after 15 and 45 min. Remarkable ·OH scavenging properties and moderate reducing power, together with the modest DPPH scavenging activity, could be responsible for the great attenuation of DNA damage after 15 min of exposure to IA, while reduction of DNA damage after 45 min could be the result in additional stimulation of the cell’s repair machinery. Our results suggest that IA displayed antigenotoxic and antioxidant properties. A broader investigation of its profile in biological systems is needed.en
dc.language.isoensr
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//sr
dc.relationhCOMET COST action (No 15132)sr
dc.rightsrestrictedAccesssr
dc.sourceMutation Research/Genetic Toxicology and Environmental Mutagenesissr
dc.subjectImmune Assist (IA)sr
dc.subjectAntigenotoxicitysr
dc.subjectOH Scavenging propertiessr
dc.titleAntigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro studyen
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractСантибанез, Јуан; Живковић, Лада; Бајић, Владан; Бруић, Марија; Борозан, Сунчица; Попић, Кристина; Топаловић, Дијана; Спремо-Потпаревиц, Биљана;
dc.citation.volume845
dc.citation.spage1
dc.citation.epage6
dc.citation.other
dc.citation.rankM22
dc.description.otherPeer-reviewed manuscripit [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3459]
dc.identifier.wos000489193400018
dc.identifier.doi10.1016/j.mrgentox.2019.06.008
dc.identifier.scopus2-s2.0-85070315567
dc.type.versionpublishedVersionsr


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