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Antigenotoxic and antioxidant potential of medicinal mushrooms (Immune Assist) against DNA damage induced by free radicals-an in vitro study

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2019
Authors
Živković, Lada
Bajić, Vladan
Bruić, Marija
Borozan, Sunčica
Popić, Kristina
Topalović, Dijana
Santibanez, Juan
Spremo-Potparević, Biljana
Article (Published version)
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Abstract
Immune Assist (IA) is produced from extract of six species of medical mushrooms: Agaricus blazei - Cordyceps sinensis - Grifola frondosa - Ganoderma lucidum - Coriolus versicolor - Lentinula edodes. The genoprotective potential of IA was evaluated for the first time. Significant antigenotoxic effects were detected in human peripheral blood cells against H2O2 induced DNA damage, in the pretreatment and in the posttreatment. The most efficient concentration of IA in pretreatment was 500 μg/mL, while in posttreatment it was the concentration of 250 μg/mL. Kinetics of attenuation of H2O2 induced DNA damage in posttreatment with the optimal concentration of IA showed significant decrease in the number of damaged cells at all time periods (15–60 min), reaching the greatest reduction after 15 and 45 min. Remarkable ·OH scavenging properties and moderate reducing power, together with the modest DPPH scavenging activity, could be responsible for the great attenuation of DNA damage after 15 min ...of exposure to IA, while reduction of DNA damage after 45 min could be the result in additional stimulation of the cell’s repair machinery. Our results suggest that IA displayed antigenotoxic and antioxidant properties. A broader investigation of its profile in biological systems is needed.

Keywords:
Immune Assist (IA) / Antigenotoxicity / OH Scavenging properties
Source:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2019, 845, 1-6
Publisher:
  • Elsevier
Projects:
  • Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)
  • hCOMET COST action (No 15132)
Note:
  • This is peer-reviewed version of the following article: Živković, L.; Bajić, V.; Bruić, M.; Borozan, S.; Popić, K.; Topalović, D.; Santibanez, J.; Spremo-Potparević, B. Antigenotoxic and Antioxidant Potential of Medicinal Mushrooms (Immune Assist) against DNA Damage Induced by Free Radicals-an in Vitro Study. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2019, 845. https://doi.org/10.1016/j.mrgentox.2019.06.008

DOI: 10.1016/j.mrgentox.2019.06.008

ISSN: 1383-5718

WoS: 000489193400018

Scopus: 2-s2.0-85070315567
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3459
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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