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dc.creatorBjørklund, Geir
dc.creatorCrisponi, Guido
dc.creatorNurchi, Valeria Marina
dc.creatorCappai, Rosita
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorAaseth, Jan
dc.date.accessioned2019-11-07T14:59:49Z
dc.date.available2019-11-07T14:59:49Z
dc.date.issued2019
dc.identifier.issn1420-3049
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3460
dc.description.abstractThe present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent British anti-Lewisite (BAL, 2,3-dimercaptopropanol) and is the recommended agent in poisonings with Pb and organic Hg. Its toxicity is also lower than that of DMPS (dimercaptopropane sulfonate), although DMPS is the recommended agent in acute poisonings with Hg salts. It is suggested that intracellular Cd deposits and cerebral deposits of inorganic Hg, to some extent, can be mobilized by a combination of antidotes, but clinical experience with such combinations are lacking. Alpha-lipoic acid (α-LA) has been suggested for toxic metal detoxification but is not considered a drug of choice in clinical practice. The molecular mechanisms and chemical equilibria of complex formation of the chelators with the metal ions Hg2+, Cd2+, and Pb2+ are reviewed since insight into these reactions can provide a basis for further development of therapeutics.en
dc.language.isoensr
dc.publisherMDPIsr
dc.relationVMN thanks Regione Autonoma della Sardegna - RASSR79857 “Metallo-farmaci innovativi: biotrasformazione e target biologici. Un approccio integrato”.sr
dc.relationInnovation Sciences and Technologies (PON RI 2014-2020) at the University of Cagliari.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccesssr
dc.sourceMoleculessr
dc.subjectBALsr
dc.subjectDMPSsr
dc.subjectDMSAsr
dc.subjectMetal chelatorsr
dc.subjectMetal ionsr
dc.titleA Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Leaden
dc.typearticlesr
dc.rights.licenseBYsr
dcterms.abstractБјøрклунд, Геир; Цриспони, Гуидо; Нурцхи, Валериа Марина; Цаппаи, Росита; Буха Дјордјевиц, Aлександра; Aасетх, Јан;
dc.citation.volume24
dc.citation.issue3247
dc.citation.spage1
dc.citation.epage32
dc.citation.rankM22
dc.identifier.wos000488830500039
dc.identifier.doi10.3390/molecules24183247
dc.identifier.pmid31489907
dc.identifier.scopus2-s2.0-85071777914
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7256/A_Review_on_pub_2019.pdf
dc.type.versionpublishedVersionsr


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