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Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy

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2020
Antioxidan_tenzymes_expression_pub_2020.pdf (918.5Kb)
Authors
Obradović, Milan
Zafirović, Sonja
Essack, Magbubah
Dimitrov, Jelena
Živković, Lada
Spremo-Potparević, Biljana
Radak, Đorđe
Bajić, Vladimir B.
Isenović, Esma
Article (Published version)
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Abstract
To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.
Keywords:
DNA damage / Acute brain ischemia / Catalase / Cerebrovascular hemoglobin oxygen saturation / Superoxide dismutase
Source:
Medical Hypotheses, 2020, 134, 1-5
Publisher:
  • Elsevier
Funding / projects:
  • Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-173033)
  • Carotid disease in Serbia - pathologic dynamics, prevention, diagnostics and inovative therapeutic methods (RS-41002)
  • Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-173034)
  • KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.

DOI: 10.1016/j.mehy.2019.109419

ISSN: 0306-9877

WoS: 000510971500004

Scopus: 2-s2.0-85073096930
[ Google Scholar ]
2
1
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3462
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Obradović, Milan
AU  - Zafirović, Sonja
AU  - Essack, Magbubah
AU  - Dimitrov, Jelena
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Radak, Đorđe
AU  - Bajić, Vladimir B.
AU  - Isenović, Esma
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3462
AB  - To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.
PB  - Elsevier
T2  - Medical Hypotheses
T1  - Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy
VL  - 134
SP  - 1
EP  - 5
DO  - 10.1016/j.mehy.2019.109419
ER  - 
@article{
author = "Obradović, Milan and Zafirović, Sonja and Essack, Magbubah and Dimitrov, Jelena and Živković, Lada and Spremo-Potparević, Biljana and Radak, Đorđe and Bajić, Vladimir B. and Isenović, Esma",
year = "2020",
abstract = "To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.",
publisher = "Elsevier",
journal = "Medical Hypotheses",
title = "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy",
volume = "134",
pages = "1-5",
doi = "10.1016/j.mehy.2019.109419"
}
Obradović, M., Zafirović, S., Essack, M., Dimitrov, J., Živković, L., Spremo-Potparević, B., Radak, Đ., Bajić, V. B.,& Isenović, E.. (2020). Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses
Elsevier., 134, 1-5.
https://doi.org/10.1016/j.mehy.2019.109419
Obradović M, Zafirović S, Essack M, Dimitrov J, Živković L, Spremo-Potparević B, Radak Đ, Bajić VB, Isenović E. Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy. in Medical Hypotheses. 2020;134:1-5.
doi:10.1016/j.mehy.2019.109419 .
Obradović, Milan, Zafirović, Sonja, Essack, Magbubah, Dimitrov, Jelena, Živković, Lada, Spremo-Potparević, Biljana, Radak, Đorđe, Bajić, Vladimir B., Isenović, Esma, "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy" in Medical Hypotheses, 134 (2020):1-5,
https://doi.org/10.1016/j.mehy.2019.109419 . .

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