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dc.creatorObradović, Milan
dc.creatorZafirović, Sonja
dc.creatorEssack, Magbubah
dc.creatorDimitrov, Jelena
dc.creatorŽivković, Lada
dc.creatorSpremo-Potparević, Biljana
dc.creatorRadak, Đorđe
dc.creatorBajić, Vladimir B.
dc.creatorIsenović, Esma
dc.date.accessioned2019-11-12T11:40:26Z
dc.date.available2019-11-12T11:40:26Z
dc.date.issued2020
dc.identifier.issn0306-9877
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3462
dc.description.abstractTo remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.en
dc.publisherElsevier
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.relationKAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceMedical Hypotheses
dc.subjectDNA damage
dc.subjectAcute brain ischemia
dc.subjectCatalase
dc.subjectCerebrovascular hemoglobin oxygen saturation
dc.subjectSuperoxide dismutase
dc.titleAntioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomyen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractИсеновић, Есма; Обрадовић, Милан; Зафировић, Соња; Радак, Ђорђе; Ессацк, Магбубах; Димитров, Јелена; Живковић, Лада; Спремо-Потпаревић, Биљана; Бајић, Владимир Б.;
dc.citation.volume134
dc.citation.spage1
dc.citation.epage5
dc.citation.rankM23
dc.identifier.wos000510971500004
dc.identifier.doi10.1016/j.mehy.2019.109419
dc.identifier.scopus2-s2.0-85073096930
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/7257/Antioxidan_tenzymes_expression_pub_2020.pdf
dc.type.versionpublishedVersion


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