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Endocrine-disrupting mechanisms of polychlorinated biphenyls

Authorized Users Only
2020
Authors
Buha-Đorđević, Aleksandra
Antonijević, Evica
Ćurčić, Marijana
Milovanović, Vesna
Antonijević, Biljana
Article (Published version)
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Abstract
The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
Keywords:
Mechanisms and modes of actions / Polychlorinated biphenyls / Reproductive endocrine disruption / Thyroid disruption
Source:
Current Opinion in Toxicology, 2020, 19, 42-49
Publisher:
  • Elsevier
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.1016/j.cotox.2019.10.006

ISSN: 2468-2020

WoS: 000531649300009

Scopus: 2-s2.0-85075071571
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/3470
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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