Endocrine-disrupting mechanisms of polychlorinated biphenyls
Authorized Users Only
2020
Authors
Buha-Đorđević, Aleksandra
Antonijević, Evica

Ćurčić, Marijana

Milovanović, Vesna
Antonijević, Biljana

Article (Published version)

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Show full item recordAbstract
The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
Keywords:
Mechanisms and modes of actions / Polychlorinated biphenyls / Reproductive endocrine disruption / Thyroid disruptionSource:
Current Opinion in Toxicology, 2020, 19, 42-49Publisher:
- Elsevier
Projects:
DOI: 10.1016/j.cotox.2019.10.006
ISSN: 2468-2020