The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
Keywords:
Mechanisms and modes of actions / Polychlorinated biphenyls / Reproductive endocrine disruption / Thyroid disruption
TY - JOUR
AU - Buha-Đorđević, Aleksandra
AU - Antonijević, Evica
AU - Ćurčić, Marijana
AU - Milovanović, Vesna
AU - Antonijević, Biljana
PY - 2020
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3470
AB - The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
PB - Elsevier
T2 - Current Opinion in Toxicology
T1 - Endocrine-disrupting mechanisms of polychlorinated biphenyls
VL - 19
SP - 42
EP - 49
DO - 10.1016/j.cotox.2019.10.006
ER -
@article{
author = "Buha-Đorđević, Aleksandra and Antonijević, Evica and Ćurčić, Marijana and Milovanović, Vesna and Antonijević, Biljana",
year = "2020",
abstract = "The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.",
publisher = "Elsevier",
journal = "Current Opinion in Toxicology",
title = "Endocrine-disrupting mechanisms of polychlorinated biphenyls",
volume = "19",
pages = "42-49",
doi = "10.1016/j.cotox.2019.10.006"
}
Buha-Đorđević, A., Antonijević, E., Ćurčić, M., Milovanović, V.,& Antonijević, B.. (2020). Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology
Elsevier., 19, 42-49.
https://doi.org/10.1016/j.cotox.2019.10.006
Buha-Đorđević A, Antonijević E, Ćurčić M, Milovanović V, Antonijević B. Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology. 2020;19:42-49.
doi:10.1016/j.cotox.2019.10.006 .
Buha-Đorđević, Aleksandra, Antonijević, Evica, Ćurčić, Marijana, Milovanović, Vesna, Antonijević, Biljana, "Endocrine-disrupting mechanisms of polychlorinated biphenyls" in Current Opinion in Toxicology, 19 (2020):42-49,
https://doi.org/10.1016/j.cotox.2019.10.006 . .
