Endocrine-disrupting mechanisms of polychlorinated biphenyls
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2020
Authors
Buha-Đorđević, AleksandraAntonijević, Evica
Ćurčić, Marijana
Milovanović, Vesna
Antonijević, Biljana
Article (Published version)
Metadata
Show full item recordAbstract
The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.
Keywords:
Mechanisms and modes of actions / Polychlorinated biphenyls / Reproductive endocrine disruption / Thyroid disruptionSource:
Current Opinion in Toxicology, 2020, 19, 42-49Publisher:
- Elsevier
Funding / projects:
- Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46009)
DOI: 10.1016/j.cotox.2019.10.006
ISSN: 2468-2020
WoS: 000531649300009
Scopus: 2-s2.0-85075071571
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Institution/Community
PharmacyTY - JOUR AU - Buha-Đorđević, Aleksandra AU - Antonijević, Evica AU - Ćurčić, Marijana AU - Milovanović, Vesna AU - Antonijević, Biljana PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3470 AB - The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action. PB - Elsevier T2 - Current Opinion in Toxicology T1 - Endocrine-disrupting mechanisms of polychlorinated biphenyls VL - 19 SP - 42 EP - 49 DO - 10.1016/j.cotox.2019.10.006 ER -
@article{ author = "Buha-Đorđević, Aleksandra and Antonijević, Evica and Ćurčić, Marijana and Milovanović, Vesna and Antonijević, Biljana", year = "2020", abstract = "The extent of human exposure to chemicals, their endocrine-disrupting mechanisms of action, and the relationship between exposure and various human diseases raise significant scientific and public health concerns. Polychlorinated biphenyls (PCBs) belong to the group of organic compounds known as persistent organic pollutants, characterized by long-range transport, persistence, bioaccumulation, and high toxicity. They have been identified as endocrine-disrupting chemicals. In vivo and in vitro studies have shown that endocrine-disrupting effects of PCBs mainly involve thyroid and reproductive function. In the review presented, these effects were placed in the context of the most recent findings on PCB-induced endocrine-disrupting mechanisms and modes of action.", publisher = "Elsevier", journal = "Current Opinion in Toxicology", title = "Endocrine-disrupting mechanisms of polychlorinated biphenyls", volume = "19", pages = "42-49", doi = "10.1016/j.cotox.2019.10.006" }
Buha-Đorđević, A., Antonijević, E., Ćurčić, M., Milovanović, V.,& Antonijević, B.. (2020). Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology Elsevier., 19, 42-49. https://doi.org/10.1016/j.cotox.2019.10.006
Buha-Đorđević A, Antonijević E, Ćurčić M, Milovanović V, Antonijević B. Endocrine-disrupting mechanisms of polychlorinated biphenyls. in Current Opinion in Toxicology. 2020;19:42-49. doi:10.1016/j.cotox.2019.10.006 .
Buha-Đorđević, Aleksandra, Antonijević, Evica, Ćurčić, Marijana, Milovanović, Vesna, Antonijević, Biljana, "Endocrine-disrupting mechanisms of polychlorinated biphenyls" in Current Opinion in Toxicology, 19 (2020):42-49, https://doi.org/10.1016/j.cotox.2019.10.006 . .