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dc.creatorČalija, Bojan
dc.creatorMilić, Jela
dc.creatorMilašinović, Nikola
dc.creatorDaković, Aleksandra
dc.creatorTrifković, Kata
dc.creatorStojanović, Jovica
dc.creatorKrajišnik, Danina
dc.date.accessioned2019-12-19T10:57:28Z
dc.date.available2019-12-19T10:57:28Z
dc.date.issued2020
dc.identifier.issn0021-8995
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3476
dc.description.abstractThis study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics.sr
dc.language.isoensr
dc.publisherWiley Periodicals, Inc.sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172018/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//sr
dc.rightsembargoedAccesssr
dc.sourceJournal of Applied Polymer Sciencesr
dc.subjectbiopolymers and renewable polymerssr
dc.subjectclaysr
dc.subjectcompositessr
dc.subjectdrug delivery systemssr
dc.subjectfilmssr
dc.titleFunctionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar masssr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dc.citation.volume137
dc.citation.issue8
dc.citation.rankM22~
dc.description.otherThis is peer-reviewed version of the following article: Čalija, B.; Milić, J.; Milašinović, N.; Daković, A.; Trifković, K.; Stojanović, J.; Krajišnik, D. Functionality of Chitosan-Halloysite Nanocomposite Films for Sustained Delivery of Antibiotics: The Effect of Chitosan Molar Mass. J. Appl. Polym. Sci. 2020, 137 (8). [https://doi.org/10.1002/app.48406]
dc.identifier.wos000482327700001
dc.identifier.doi10.1002/app.48406
dc.identifier.scopus2-s2.0-85070936288
dc.type.versionpublishedVersion
dc.type.versionacceptedVersionsr


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