Приказ основних података о документу

dc.creatorŽivković, Lada
dc.creatorBajić, Vladan
dc.creatorTopalović, Dijana
dc.creatorBruić, Marija
dc.creatorSpremo-Potparević, Biljana
dc.date.accessioned2020-01-09T16:23:36Z
dc.date.available2020-01-09T16:23:36Z
dc.date.issued2019
dc.identifier.issn1942-0900
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3484
dc.description.abstractThe health benefits of natural products have long been recognized. Consumption of dietary compounds such as supplements provides an alternative source of natural products to those obtained from the diet. There is a growing concern regarding the possible side effects of using different food supplements simultaneously, since their possible interactions are less known. For the first time, we have tested genotoxic and antigenotoxic effects of Biochaga, in combination with dihydroquercetin. No genotoxic effect on whole blood cells was observed within individual treatment of Biochaga (250 μg/mL, 500 μg/mL and 1000 μg/mL) and dihydroquercetin (100 μg/mL, 250 μg/mL and 500 μg/mL), nor in combination. Afterwards, antigenotoxic potency of both supplements against hydrogen peroxide- (H2O2-) induced DNA damage to whole blood cells (WBC) was assessed, using the comet assay. Biochaga and dihydroquercetin displayed a strong potential to attenuate H2O2-induced damage on DNA in cells at all tested concentrations, with a statistical significance (p < 0:05), whereas Biochaga at the dose of 500 μg/mL in combination with dihydroquercetin 500 μg/mL was most prominent. Biochaga in combination with dihydroquercetin is able to protect genomic material from oxidative damage induced by hydrogen peroxide in vitro.en
dc.publisherHindawi
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.relationhCOMET COST (Action No. CA 15132)
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceOxidative Medicine and Cellular Longevity
dc.subjectAntigens
dc.subjectCells
dc.subjectCytology
dc.subjectDamage detection
dc.subjectDietary supplements
dc.subjectDNA
dc.subjectHydrogen peroxide
dc.subjectOxidation
dc.subjectPeroxides
dc.titleAntigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cellsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТопаловић, Дијана; Бајић, Владан; Спремо-Потпаревић, Биљана; Живковић, Лада; Бруић, Марија;
dc.citation.volume2019
dc.citation.rankM21
dc.identifier.wos000499161600016
dc.identifier.doi10.1155/2019/5039372
dc.identifier.scopus2-s2.0-85075739394
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/7393/bitstream_7393.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу