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Da li je endokan novi potencijalni biomarker za steatozu i fibrozu jetre?

dc.creatorKlisić, Aleksandra
dc.creatorKavarić, Nebojša
dc.creatorAbenavoli, Ludovico
dc.creatorStanišić, Verica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorKotur-Stevuljević, Jelena
dc.creatorNinić, Ana
dc.date.accessioned2020-01-10T15:39:04Z
dc.date.available2020-01-10T15:39:04Z
dc.date.issued2020
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/3485
dc.description.abstractStudies that evaluated endocan levels in nonalcoholic fatty liver disease (NAFLD) and liver fibrosis are scarce. We aimed to explore endocan levels in relation to different stages of liver diseases, such as NAFLD, as determined with fatty liver index (FLI) and liver fibrosis, as assessed with BARD score. A total of 147 participants with FLI≥60 were compared with 64 participants with FLI <30. An FLI score was calculated using waist circumference, body mass index, gamma-glutamyl transferase and triglycerides. Patients with FLI≥60 were further divided into those with no/mild fibrosis (BARD score 0-1 point; n=23) and advanced fibrosis (BARD score 2-4 points; n=124). BARD score was calculated as follows: diabetes mellitus (1 point) + body mass index≥28 kg/m2 (1 point) + aspartate amino transferase/alanine aminotransferase ratio≥0.8 (2 points). Endocan was independent predictor for FLI and BARD score, both in univariate [OR=1.255 (95% CI= 1.104-1.426), P=0.001; OR=1.208 (95% CI=1.029- 1.419), P=0.021, respectively] and multivariate binary logistic regression analysis [OR=1.287 (95% CI=1.055- 1.570), P=0.013; OR=1.226 (95% CI=1.022-1.470), P=0.028, respectively]. Endocan as a single predictor showed poor discriminatory capability for steatosis/fibrosis [AUC=0.648; (95% CI=0.568-0.727), P=0.002; AUC= 0.667 (95% CI=0.555-0.778), P=0.013, respectively], whereas in a Model, endocan showed an excellent clinical accuracy [AUC=0.930; (95% CI=0.886-0.975), P<0.001, AUC=0.840 (95% CI=0.763-0.918), P<0.001, respectively]. Endocan independently correlated with both FLI and BARD score. However, when tested in models (with other biomarkers), endocan showed better discriminatory ability for liver steatosis/fibrosis, instead of its usage as a single biomarker
dc.description.abstractUvod: Nema mnogo studija koje su ispitivale vrednosti endokana kod obolelih od nealkoholne steatoze i fibroze jetre. Naš cilj je bio da se ispita nivo endokana u različitim stadijumima oboljenja jetre, kao što su nealkoholna steatoza jetre, predstavljena indeksom masne jetre (FLI) i fibroza jetre, predstavljena BARD skorom. Metode: Ukupno 147 učesnika sa FLI≥60 poređeno je sa 64 učesnika sa FLI <30. FLI skor je izračunat koriste i vrednosti obim struka, indeksa telesne mase, aktivnosti gama-glutamil transferaze i vrednosti triglicerida. Ispitanici sa FLI≥60 su dalje podeljeni u 2 grupe: bez fibroze/blaga fibroza (BARD skor 0–1 poen; n=23) i uznapredovala fibroza (BARD skor 2–4 poena; n=124). BARD skor je računat na sledeći način: e erna bolest (1 poen) + indeks telesne mase≥28 kg/m2 (1 poen) + odnos aspartat aminotransferaza/alanin aminotransferaza≥0,8 (2 poena). Rezultati: Endokan je nezavisan prediktor FLI i BARD skora, kako u univarijantnoj [OR=1,255 (95% CI=1,104– 1,426), P=0,001; odnosno OR=1,208 (95% CI=1,029– 1,419), P=0,021], tako i u multivarijantnoj binarnoj logističkoj regresionoj analizi [OR=1.287 (95% CI=1,055– 1,570), P=0,013; odnosno OR=1,226 (95% CI=1,022– 1,470), P=0,028]. Endokan kao samostalan prediktor pokazao je slabu diskriminatornu mo za steatozu/fibrozu jetre [AUC=0,648; (95% CI=0,568–0,727), P=0,002; odnosno AUC=0,667 (95% CI=0,555–0,778), P=0,013], ali je u Modelu pokazao odličnu kliničku tačnost [AUC=0,930; (95% CI=0,886–0,975), P<0,001; odnosno AUC=0,840 (95% CI=0,763–0,918), P<0,001]. Zaključak: Endokan je nezavisno povezan kako sa FLI, tako i sa BARD skorom. Ipak, u modelu (sa drugim biomarkerima), endokan je pokazao bolju diskriminatornu sposobnost za steatozu/fibrozu jetre.
dc.publisherBelgrade: Society of Medical Biochemists of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectcardiovascular disease
dc.subjectendocan
dc.subjectinflammation
dc.subjectliver fibrosis
dc.subjectliver steatosis
dc.subjectendokan
dc.subjectinflamacija
dc.subjectsteatoza jetre
dc.subjectfibroza jetre
dc.subjectkardiovaskularne bolesti
dc.titleIs endocan a novel potential biomarker of liver steatosis and fibrosis?
dc.titleDa li je endokan novi potencijalni biomarker za steatozu i fibrozu jetre?
dc.typearticle
dc.rights.licenseBY
dcterms.abstractНинић, Aна; Клисић, Aлександра; Каварић, Небојша; Aбенаволи, Лудовицо; Станишић, Верица; Спасојевић-Калимановска, Весна; Котур-Стевуљевић, Јелена; ДA ЛИ ЈЕ ЕНДОКAН НОВИ ПОТЕНЦИЈAЛНИ БИОМAРКЕР ЗA СТЕAТОЗУ И ФИБРОЗУ ЈЕТРЕ?; Ис ендоцан а новел потентиал биомаркер оф ливер стеатосис анд фибросис?;
dc.citation.volume39
dc.citation.issue3
dc.citation.spage363
dc.citation.epage371
dc.citation.rankM23~
dc.identifier.wos000543795100012
dc.identifier.doi10.2478/jomb-2019-0042
dc.identifier.scopus2-s2.0-85075758623
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/7842/Is_endocan_a_pub_2020.pdf
dc.type.versionpublishedVersion


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