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dc.creatorAwad, Mahmoud E.
dc.creatorLópez-Galindo, Alberto
dc.creatorMedarević, Đorđe
dc.creatorĐuriš, Jelena
dc.creatorEl-Rahmany, Mahmoud M.
dc.creatorIbrić, Svetlana
dc.creatorViseras, César
dc.date.accessioned2020-02-07T10:44:13Z
dc.date.available2020-02-07T10:44:13Z
dc.date.issued2020
dc.identifier.issn2075-163X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3496
dc.description.abstractThe present work aimed at assessing the pharmaceutical tableting properties of some Egyptian kaolin samples belong to the Abu Zenima kaolin deposits (estimated at 120 million tons). Four representative samples were selected based on kaolinite richness and their structural order-disorder degree, and after purification, they were dried at 70 C and heated from room temperature up to 400 C (10 C/min). Mineralogy, micromorphology, microtexture, granulometry, porosimetry, moisture content, bulk and tapped density, direct and indirect flowability, and tableting characteristics are studied. Results indicated that purified kaolin samples were made up of 95–99% kaolinite, <3% illite, 1% quartz and 1% anatase. The powder showed mesoporous character (pore diameters from 2 to 38 nm and total pore volume from 0.064 to 0.136 cm3/g) with dominance of fine nanosized particles (<1 m–10 nm). The powder flow characteristics of both the ordered (Hinckley Index HI > 0.7, crystallite size D001 > 30 nm) and disordered (HI < 0.7, D001 < 30 nm) kaolinite-rich samples have been improved (Hausner ratio between 1.24 and 1.09) as their densities were influenced by thermal treatment (with some observed changes in the kaolinite XRD reflection profiles) and by moisture content (variable between 2.98% and 5.82%). The obtained tablets exhibited hardness between 33 and 44 N only from the dehydrated powders at 400 C, with elastic recovery (ER) between 21.74% and 25.61%, ejection stress (ES) between 7.85 and 11.45 MPa and tensile fracture stress (TFS) between 1.85 and 2.32 MPa, which are strongly correlated with crystallinity (HI) and flowability (HR) parameters. These findings on quality indicators showed the promising pharmaceutical tabletability of the studied Egyptian kaolin powders and the optimization factors for their manufacturability and compactability.en
dc.publisherMDPI
dc.relationEgyptian Cultural Affairs and Missions Sector (Plan 2013–2014)
dc.relationMinistry of Higher Education, in collaboration with the Group CTS-946 (Junta de Andalucía).
dc.relationMINECO projectCGL2016-80833-R (Spain)
dc.relationThe grant funded by Erasmus+ KA1 mobility program 2016/2017
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMinerals
dc.subjectEgyptian kaolin
dc.subjectFlowability
dc.subjectManufacturability
dc.subjectMicrometrics
dc.subjectMicrostructure
dc.subjectPowder
dc.subjectTable hardness
dc.subjectTableting properties
dc.titleFlow and tableting behaviors of some egyptian kaolin powders as potential pharmaceutical excipientsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМедаревић, Ђорђе; Ђуриш, Јелена; Ибрић, Светлана; Awад, Махмоуд Е.; Лóпез-Галиндо, Aлберто; Ел-Рахманy, Махмоуд М.; Висерас, Цéсар;
dc.citation.volume10
dc.citation.issue1
dc.citation.rankM21
dc.identifier.wos000522452300023
dc.identifier.doi10.3390/min10010023
dc.identifier.scopus2-s2.0-85077469009
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/7462/Flow_and_Tableting_pub_2020.pdf
dc.type.versionpublishedVersion


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